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Xiangling Li, Xinshuo Huang, Jingshan Mo, Hao Wang, Qiqi Huang, Cheng Yang, Tao Zhang, Hui‐Jiuan Chen, Tian Hang, Fanmao Liu and 5 more
A closed-loop system that can mini-invasively track blood glucose and intelligently treat diabetes is in great demand for modern medicine, yet it remains challenging to realize. Microneedles technologies have recently emerged as powerful tools for transdermal applications with inherent painlessness and biosafety. In this work, for the first time to the authors' knowledge, a fully integrated wearable closed-loop system (IWCS) based on mini-invasive microneedle platform is developed for in situ diabetic sensing and treatment. The IWCS consists of three connected modules: 1) a mesoporous microneedle-reverse iontophoretic glucose sensor; 2) a flexible printed circuit board as integrated and control; and 3) a microneedle-iontophoretic insulin delivery component. As the key component, mesoporous microneedles enable the painless penetration of stratum corneum, implementing subcutaneous substance exchange. The coupling with iontophoresis significantly enhances glucose extraction and insulin delivery and enables electrical control. This IWCS is demonstrated to accurately monitor glucose fluctuations, and responsively deliver insulin to regulate hyperglycemia in diabetic rat model. The painless microneedles and wearable design endows this IWCS as a highly promising platform to improve the therapies of diabetic patients.
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Li, X., Huang, X., Mo, J., Wang, H., Huang, Q., Yang, C., Zhang, T., Chen, H., Hang, T., Liu, F., Jiang, L., Wu, Q., Li, H., Hu, N., & Xie, X. (2021). A Fully Integrated Closed‐Loop System Based on Mesoporous Microneedles‐Iontophoresis for Diabetes Treatment. Advanced Science, 8(16), e2100827. https://doi.org/10.1002/advs.202100827
Li, Xiangling, et al. "A Fully Integrated Closed‐Loop System Based on Mesoporous Microneedles‐Iontophoresis for Diabetes Treatment." Advanced Science, vol. 8, no. 16, 2021, pp. e2100827, https://doi.org/10.1002/advs.202100827.
Li, Xiangling, Xinshuo Huang, Jingshan Mo, Hao Wang, Qiqi Huang, Cheng Yang, Tao Zhang, et al. "A Fully Integrated Closed‐Loop System Based on Mesoporous Microneedles‐Iontophoresis for Diabetes Treatment." Advanced Science 8, no. 16 (2021): e2100827. https://doi.org/10.1002/advs.202100827.
Li X., Huang X., Mo J. [и др.] A Fully Integrated Closed‐Loop System Based on Mesoporous Microneedles‐Iontophoresis for Diabetes Treatment // Advanced Science. — 2021. — Vol. 8, № 16. — P. e2100827. — URL: https://doi.org/10.1002/advs.202100827
@article{li2021fully,
title = {{A Fully Integrated Closed‐Loop System Based on Mesoporous Microneedles‐Iontophoresis for Diabetes Treatment}},
author = {Xiangling Li and Xinshuo Huang and Jingshan Mo and Hao Wang and Qiqi Huang and Cheng Yang and Tao Zhang and Hui‐Jiuan Chen and Tian Hang and Fanmao Liu and Lelun Jiang and Qianni Wu and Hongbo Li and Ning Hu and Xi Xie},
journal = {Advanced Science},
year = {2021},
volume = {8},
number = {16},
pages = {e2100827},
doi = {10.1002/advs.202100827},
url = {https://doi.org/10.1002/advs.202100827}
}TY - JOUR AU - Li, Xiangling AU - Huang, Xinshuo AU - Mo, Jingshan AU - Wang, Hao AU - Huang, Qiqi AU - Yang, Cheng AU - Zhang, Tao AU - Chen, Hui‐Jiuan AU - Hang, Tian AU - Liu, Fanmao AU - Jiang, Lelun AU - Wu, Qianni AU - Li, Hongbo AU - Hu, Ning AU - Xie, Xi TI - A Fully Integrated Closed‐Loop System Based on Mesoporous Microneedles‐Iontophoresis for Diabetes Treatment JO - Advanced Science VL - 8 IS - 16 SP - e2100827 PY - 2021 DA - 2021/06/03 DO - 10.1002/advs.202100827 UR - https://doi.org/10.1002/advs.202100827 ER -
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