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Hua Liu, Zhengwei Cai, Fei Wang, Liwen Hong, Lianfu Deng, Jie Zhong, Zhengting Wang, Wenguo Cui
Intestinal immune homeostasis and microbiome structure play a critical role in the pathogenesis and progress of inflammatory bowel disease (IBD), whereas IBD treatment remains a challenge as the first-line drugs show limited therapeutic efficiency and great side effect. In this study, a colon-targeted adhesive core-shell hydrogel microsphere is designed and fabricated by the ingenious combination of advanced gas-shearing technology and ionic diffusion method, which can congregate on colon tissue regulating the gut immune-microbiota microenvironment in IBD treatment. The degradation experiment indicates the anti-acid and colon-targeted property of the alginate hydrogel shell, and the in vivo imaging shows the mucoadhesive ability of the thiolated-hyaluronic acid hydrogel core of the microsphere, which reduces the systematic exposure and prolongs the local drug dwell time. In addition, both in vitro and in vivo study demonstrate that the microsphere significantly reduces the secretion of pro-inflammatory cytokines, induces specific type 2 macrophage differentiation, and remarkably alleviates colitis in the mice model. Moreover, 16S ribosomal RNA sequencing reveals an optimized gut flora composition, probiotics including Bifidobacterium and Lactobacillus significantly augment, while the detrimental communities are inhibited, which benefits the intestinal homeostasis. This finding provides an ideal clinical candidate for IBD treatment.
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Liu, H., Cai, Z., Wang, F., Hong, L., Deng, L., Zhong, J., Wang, Z., & Cui, W. (2021). Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora. Advanced Science, 8(18), e2101619. https://doi.org/10.1002/advs.202101619
Liu, Hua, et al. "Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora." Advanced Science, vol. 8, no. 18, 2021, pp. e2101619, https://doi.org/10.1002/advs.202101619.
Liu, Hua, Zhengwei Cai, Fei Wang, Liwen Hong, Lianfu Deng, Jie Zhong, Zhengting Wang, and Wenguo Cui. "Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora." Advanced Science 8, no. 18 (2021): e2101619. https://doi.org/10.1002/advs.202101619.
Liu H., Cai Z., Wang F. [и др.] Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora // Advanced Science. — 2021. — Vol. 8, № 18. — P. e2101619. — URL: https://doi.org/10.1002/advs.202101619
@article{liu2021colontargeted,
title = {{Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora}},
author = {Hua Liu and Zhengwei Cai and Fei Wang and Liwen Hong and Lianfu Deng and Jie Zhong and Zhengting Wang and Wenguo Cui},
journal = {Advanced Science},
year = {2021},
volume = {8},
number = {18},
pages = {e2101619},
doi = {10.1002/advs.202101619},
url = {https://doi.org/10.1002/advs.202101619}
}TY - JOUR AU - Liu, Hua AU - Cai, Zhengwei AU - Wang, Fei AU - Hong, Liwen AU - Deng, Lianfu AU - Zhong, Jie AU - Wang, Zhengting AU - Cui, Wenguo TI - Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora JO - Advanced Science VL - 8 IS - 18 SP - e2101619 PY - 2021 DA - 2021/07/22 DO - 10.1002/advs.202101619 UR - https://doi.org/10.1002/advs.202101619 ER -
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