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Theresia Stich, Francisca I. Alagboso, Tomáš Křenek, Tomáš Kovářík, Volker Alt, Denitsa Docheva
Titanium is commonly and successfully used in dental and orthopedic implants. However, patients still have to face the risk of implant failure due to various reasons, such as implant loosening or infection. The risk of implant loosening can be countered by optimizing the osteointegration capacity of implant materials. Implant surface modifications for structuring, roughening and biological activation in favor for osteogenic differentiation have been vastly studied. A key factor for a successful stable long-term integration is the initial cellular response to the implant material. Hence, cell-material interactions, which are dependent on the surface parameters, need to be considered in the implant design. Therefore, this review starts with an introduction to the basics of cell-material interactions as well as common surface modification techniques. Afterwards, recent research on the impact of osteogenic processes in vitro and vivo provoked by various surface modifications is reviewed and discussed, in order to give an update on currently applied and developing implant modification techniques for enhancing osteointegration.
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Stich, T., Alagboso, F. I., Křenek, T., Kovářík, T., Alt, V., & Docheva, D. (2021). Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo. Bioengineering & Translational Medicine, 7(1), e10239. https://doi.org/10.1002/btm2.10239
Stich, Theresia, et al. "Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo." Bioengineering & Translational Medicine, vol. 7, no. 1, 2021, pp. e10239, https://doi.org/10.1002/btm2.10239.
Stich, Theresia, Francisca I. Alagboso, Tomáš Křenek, Tomáš Kovářík, Volker Alt, and Denitsa Docheva. "Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo." Bioengineering & Translational Medicine 7, no. 1 (2021): e10239. https://doi.org/10.1002/btm2.10239.
Stich T., Alagboso F. I., Křenek T. [и др.] Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo // Bioengineering & Translational Medicine. — 2021. — Vol. 7, № 1. — P. e10239. — URL: https://doi.org/10.1002/btm2.10239
@article{stich2021implantboneinterface,
title = {{Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo}},
author = {Theresia Stich and Francisca I. Alagboso and Tomáš Křenek and Tomáš Kovářík and Volker Alt and Denitsa Docheva},
journal = {Bioengineering \& Translational Medicine},
year = {2021},
volume = {7},
number = {1},
pages = {e10239},
doi = {10.1002/btm2.10239},
url = {https://doi.org/10.1002/btm2.10239}
}TY - JOUR AU - Stich, Theresia AU - Alagboso, Francisca I. AU - Křenek, Tomáš AU - Kovářík, Tomáš AU - Alt, Volker AU - Docheva, Denitsa TI - Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo JO - Bioengineering & Translational Medicine VL - 7 IS - 1 SP - e10239 PY - 2021 DA - 2021/06/26 DO - 10.1002/btm2.10239 UR - https://doi.org/10.1002/btm2.10239 ER -
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