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Kristine R. Crews, Andrew A. Monte, Rachel Huddart, Kelly E. Caudle, Evan D. Kharasch, Andrea Gaedigk, Henry Mark Dunnenberger, James Steven Leeder, John Thomas Callaghan, Caroline Flora Samer and 11 more
Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone). Polymorphisms in CYP2D6 have been studied for an association with the clinical effect and safety of these drugs. Other genes that have been studied for their association with opioid clinical effect or adverse events include OPRM1 (mu receptor) and COMT (catechol-O-methyltransferase). This guideline updates and expands the 2014 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 genotype and codeine therapy and includes a summation of the evidence describing the impact of CYP2D6, OPRM1, and COMT on opioid analgesia and adverse events. We provide therapeutic recommendations for the use of CYP2D6 genotype results for prescribing codeine and tramadol and describe the limited and/or weak data for CYP2D6 and hydrocodone, oxycodone, and methadone, and for OPRM1 and COMT for clinical use.
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Crews, K. R., Monte, A. A., Huddart, R., Caudle, K. E., Kharasch, E. D., Gaedigk, A., Dunnenberger, H. M., Leeder, J. S., Callaghan, J. T., Samer, C. F., Klein, T. E., Haidar, C. E., Driest, S. L. V., Ruaño, G., Sangkuhl, K., Cavallari, L. H., Müller, D. J., Prows, C. A., Nagy, M., … Skaar, T. C. (2021). Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 , OPRM1 , and COMT Genotypes and Select Opioid Therapy. Clinical Pharmacology & Therapeutics, 110(4), 888–896. https://doi.org/10.1002/cpt.2149
Crews, Kristine R., et al. "Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 , OPRM1 , and COMT Genotypes and Select Opioid Therapy." Clinical Pharmacology & Therapeutics, vol. 110, no. 4, 2021, pp. 888–896, https://doi.org/10.1002/cpt.2149.
Crews, Kristine R., Andrew A. Monte, Rachel Huddart, Kelly E. Caudle, Evan D. Kharasch, Andrea Gaedigk, Henry Mark Dunnenberger, et al. "Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 , OPRM1 , and COMT Genotypes and Select Opioid Therapy." Clinical Pharmacology & Therapeutics 110, no. 4 (2021): 888–896. https://doi.org/10.1002/cpt.2149.
Crews K. R., Monte A. A., Huddart R. [и др.] Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 , OPRM1 , and COMT Genotypes and Select Opioid Therapy // Clinical Pharmacology & Therapeutics. — 2021. — Vol. 110, № 4. — P. 888–896. — URL: https://doi.org/10.1002/cpt.2149
@article{crews2021clinical,
title = {{Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 , OPRM1 , and COMT Genotypes and Select Opioid Therapy}},
author = {Kristine R. Crews and Andrew A. Monte and Rachel Huddart and Kelly E. Caudle and Evan D. Kharasch and Andrea Gaedigk and Henry Mark Dunnenberger and James Steven Leeder and John Thomas Callaghan and Caroline Flora Samer and Teri E. Klein and Cyrine E. Haidar and Sara L. Van Driest and Gualberto Ruaño and Katrin Sangkuhl and Larisa H. Cavallari and Daniel J. Müller and Cynthia A. Prows and Mohamed Nagy and Andrew Alexander Somogyi and Todd C. Skaar},
journal = {Clinical Pharmacology \& Therapeutics},
year = {2021},
volume = {110},
number = {4},
pages = {888--896},
doi = {10.1002/cpt.2149},
url = {https://doi.org/10.1002/cpt.2149}
}TY - JOUR AU - Crews, Kristine R. AU - Monte, Andrew A. AU - Huddart, Rachel AU - Caudle, Kelly E. AU - Kharasch, Evan D. AU - Gaedigk, Andrea AU - Dunnenberger, Henry Mark AU - Leeder, James Steven AU - Callaghan, John Thomas AU - Samer, Caroline Flora AU - Klein, Teri E. AU - Haidar, Cyrine E. AU - Driest, Sara L. Van AU - Ruaño, Gualberto AU - Sangkuhl, Katrin AU - Cavallari, Larisa H. AU - Müller, Daniel J. AU - Prows, Cynthia A. AU - Nagy, Mohamed AU - Somogyi, Andrew Alexander AU - Skaar, Todd C. TI - Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 , OPRM1 , and COMT Genotypes and Select Opioid Therapy JO - Clinical Pharmacology & Therapeutics VL - 110 IS - 4 SP - 888 EP - 896 PY - 2021 DA - 2021/01/02 DO - 10.1002/cpt.2149 UR - https://doi.org/10.1002/cpt.2149 ER -
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