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Craig R. Lee, Jasmine A. Luzum, Katrin Sangkuhl, Roseann S. Gammal, Marc S. Sabatine, Charles Michael Stein, David F. Kisor, Nita A. Limdi, Yee Ming Lee, Stuart Alexander Scott and 7 more
CYP2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19 genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor metabolizers who receive clopidogrel experience reduced platelet inhibition and increased risk for major adverse cardiovascular and cerebrovascular events. This guideline is an update to the 2013 Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for the use of clopidogrel based on CYP2C19 genotype and includes expanded indications for CYP2C19 genotype-guided antiplatelet therapy, increased strength of recommendation for CYP2C19 intermediate metabolizers, updated CYP2C19 genotype to phenotype translation, and evidence from an expanded literature review (updates at www.cpicpgx.org).
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Lee, C. R., Luzum, J. A., Sangkuhl, K., Gammal, R. S., Sabatine, M. S., Stein, C. M., Kisor, D. F., Limdi, N. A., Lee, Y. M., Scott, S. A., Hulot, J., Roden, D. M., Gaedigk, A., Caudle, K. E., Klein, T. E., Johnson, J. A., & Shuldiner, A. R. (2022). Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update. Clinical Pharmacology & Therapeutics, 112(5), 959–967. https://doi.org/10.1002/cpt.2526
Lee, Craig R., et al. "Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update." Clinical Pharmacology & Therapeutics, vol. 112, no. 5, 2022, pp. 959–967, https://doi.org/10.1002/cpt.2526.
Lee, Craig R., Jasmine A. Luzum, Katrin Sangkuhl, Roseann S. Gammal, Marc S. Sabatine, Charles Michael Stein, David F. Kisor, et al. "Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update." Clinical Pharmacology & Therapeutics 112, no. 5 (2022): 959–967. https://doi.org/10.1002/cpt.2526.
Lee C. R., Luzum J. A., Sangkuhl K. [и др.] Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update // Clinical Pharmacology & Therapeutics. — 2022. — Vol. 112, № 5. — P. 959–967. — URL: https://doi.org/10.1002/cpt.2526
@article{lee2022clinical,
title = {{Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update}},
author = {Craig R. Lee and Jasmine A. Luzum and Katrin Sangkuhl and Roseann S. Gammal and Marc S. Sabatine and Charles Michael Stein and David F. Kisor and Nita A. Limdi and Yee Ming Lee and Stuart Alexander Scott and Jean‐Sébastien Hulot and Dan M. Roden and Andrea Gaedigk and Kelly E. Caudle and Teri E. Klein and Julie A. Johnson and Alan R. Shuldiner},
journal = {Clinical Pharmacology \& Therapeutics},
year = {2022},
volume = {112},
number = {5},
pages = {959--967},
doi = {10.1002/cpt.2526},
url = {https://doi.org/10.1002/cpt.2526}
}TY - JOUR AU - Lee, Craig R. AU - Luzum, Jasmine A. AU - Sangkuhl, Katrin AU - Gammal, Roseann S. AU - Sabatine, Marc S. AU - Stein, Charles Michael AU - Kisor, David F. AU - Limdi, Nita A. AU - Lee, Yee Ming AU - Scott, Stuart Alexander AU - Hulot, Jean‐Sébastien AU - Roden, Dan M. AU - Gaedigk, Andrea AU - Caudle, Kelly E. AU - Klein, Teri E. AU - Johnson, Julie A. AU - Shuldiner, Alan R. TI - Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update JO - Clinical Pharmacology & Therapeutics VL - 112 IS - 5 SP - 959 EP - 967 PY - 2022 DA - 2022/01/16 DO - 10.1002/cpt.2526 UR - https://doi.org/10.1002/cpt.2526 ER -
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