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Lea-Adriana Keller, Olivia M. Merkel, Andreas Popp
Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has increased. This review article summarises information on intranasal administration for local and systemic delivery, as well as for CNS indications. Nasal delivery offers many advantages over standard systemic delivery systems, such as its non-invasive character, a fast onset of action and in many cases reduced side effects due to a more targeted delivery. There are still formulation limitations and toxicological aspects to be optimised. Intranasal drug delivery in the field of drug development is an interesting delivery route for the treatment of neurological disorders. Systemic approaches often fail to efficiently supply the CNS with drugs. This review paper describes the anatomical, histological and physiological basis and summarises currently approved drugs for administration via intranasal delivery. Further, the review focuses on toxicological considerations of intranasally applied compounds and discusses formulation aspects that need to be considered for drug development.
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Keller, L.-A., Merkel, O. M., & Popp, A. (2021). Intranasal drug delivery: opportunities and toxicologic challenges during drug development. Drug Delivery and Translational Research, 12(4), 735–757. https://doi.org/10.1007/s13346-020-00891-5
Keller, Lea-Adriana, et al. "Intranasal drug delivery: opportunities and toxicologic challenges during drug development." Drug Delivery and Translational Research, vol. 12, no. 4, 2021, pp. 735–757, https://doi.org/10.1007/s13346-020-00891-5.
Keller, Lea-Adriana, Olivia M. Merkel, and Andreas Popp. "Intranasal drug delivery: opportunities and toxicologic challenges during drug development." Drug Delivery and Translational Research 12, no. 4 (2021): 735–757. https://doi.org/10.1007/s13346-020-00891-5.
Keller L.-A., Merkel O. M., Popp A. Intranasal drug delivery: opportunities and toxicologic challenges during drug development // Drug Delivery and Translational Research. — 2021. — Vol. 12, № 4. — P. 735–757. — URL: https://doi.org/10.1007/s13346-020-00891-5
@article{keller2021intranasal,
title = {{Intranasal drug delivery: opportunities and toxicologic challenges during drug development}},
author = {Lea-Adriana Keller and Olivia M. Merkel and Andreas Popp},
journal = {Drug Delivery and Translational Research},
year = {2021},
volume = {12},
number = {4},
pages = {735--757},
doi = {10.1007/s13346-020-00891-5},
url = {https://doi.org/10.1007/s13346-020-00891-5}
}TY - JOUR AU - Keller, Lea-Adriana AU - Merkel, Olivia M. AU - Popp, Andreas TI - Intranasal drug delivery: opportunities and toxicologic challenges during drug development JO - Drug Delivery and Translational Research VL - 12 IS - 4 SP - 735 EP - 757 PY - 2021 DA - 2021/01/24 DO - 10.1007/s13346-020-00891-5 UR - https://doi.org/10.1007/s13346-020-00891-5 ER -
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