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Jae Hwan Jung, Sung Giu Jin
Background: Transdermal delivery has the advantage of bypassing the first-pass effect and allowing sustained release of the drug. However, the drug delivery is limited owing to the barrier created by the stratum corneum. Microneedles are a transdermal drug delivery system that is painless, less invasive, and easy to self-administer, with a high drug bioavailability. Area covered: The dose, delivery rate, and efficacy of the drugs can be controlled by the microneedle design and drug formulations. This review introduces the types of microneedles and their design, materials used for fabrication, and manufacturing methods. Additionally, recent biological applications and clinical trials are introduced. Expert opinion: With advancements made in formulation technologies, the drug-loading capability of microneedles can be improved. 3D printing and digital technology contribute to the improvement of microneedle fabrication technology. However, regulations regarding the manufacture of microneedle products should be established as soon as possible to promote commercialization.
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Jung, J. H., & Jin, S. G. (2021). Microneedle for transdermal drug delivery: current trends and fabrication. Journal of Pharmaceutical Investigation, 51(5), 503–517. https://doi.org/10.1007/s40005-021-00512-4
Jung, Jae Hwan, and Sung Giu Jin. "Microneedle for transdermal drug delivery: current trends and fabrication." Journal of Pharmaceutical Investigation, vol. 51, no. 5, 2021, pp. 503–517, https://doi.org/10.1007/s40005-021-00512-4.
Jung, Jae Hwan, and Sung Giu Jin. "Microneedle for transdermal drug delivery: current trends and fabrication." Journal of Pharmaceutical Investigation 51, no. 5 (2021): 503–517. https://doi.org/10.1007/s40005-021-00512-4.
Jung J. H., Jin S. G. Microneedle for transdermal drug delivery: current trends and fabrication // Journal of Pharmaceutical Investigation. — 2021. — Vol. 51, № 5. — P. 503–517. — URL: https://doi.org/10.1007/s40005-021-00512-4
@article{jung2021microneedle,
title = {{Microneedle for transdermal drug delivery: current trends and fabrication}},
author = {Jae Hwan Jung and Sung Giu Jin},
journal = {Journal of Pharmaceutical Investigation},
year = {2021},
volume = {51},
number = {5},
pages = {503--517},
doi = {10.1007/s40005-021-00512-4},
url = {https://doi.org/10.1007/s40005-021-00512-4}
}TY - JOUR AU - Jung, Jae Hwan AU - Jin, Sung Giu TI - Microneedle for transdermal drug delivery: current trends and fabrication JO - Journal of Pharmaceutical Investigation VL - 51 IS - 5 SP - 503 EP - 517 PY - 2021 DA - 2021/03/04 DO - 10.1007/s40005-021-00512-4 UR - https://doi.org/10.1007/s40005-021-00512-4 ER -
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