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Siyu He, Li Wu, Xue Li, Hongyu Sun, Ting Xiong, Jie Liu, Chengxi Huang, Huipeng Xu, Huimin Sun, Weidong Chen, Ruxandra Gref, Jiwen Zhang
coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size and shape, and easy surface functionalization make this large family more and more popular for drug delivery. There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications. This article presents an overall review and perspectives of MOFs-based drug delivery systems (DDSs), starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands. Then, the synthesis and characterization of MOFs for DDSs are developed, followed by the drug loading strategies, applications, biopharmaceutics and quality control. Importantly, a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics, diseases therapy and advanced DDSs. In particular, the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed. Finally, challenges in MOFs development for DDSs are discussed, such as biostability, biosafety, biopharmaceutics and nomenclature.
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He, S., Wu, L., Li, X., Sun, H., Xiong, T., Liu, J., Huang, C., Xu, H., Sun, H., Chen, W., Gref, R., & Zhang, J. (2021). Metal-organic frameworks for advanced drug delivery. Acta Pharmaceutica Sinica B, 11(8), 2362–2395. https://doi.org/10.1016/j.apsb.2021.03.019
He, Siyu, et al. "Metal-organic frameworks for advanced drug delivery." Acta Pharmaceutica Sinica B, vol. 11, no. 8, 2021, pp. 2362–2395, https://doi.org/10.1016/j.apsb.2021.03.019.
He, Siyu, Li Wu, Xue Li, Hongyu Sun, Ting Xiong, Jie Liu, Chengxi Huang, et al. "Metal-organic frameworks for advanced drug delivery." Acta Pharmaceutica Sinica B 11, no. 8 (2021): 2362–2395. https://doi.org/10.1016/j.apsb.2021.03.019.
He S., Wu L., Li X. [и др.] Metal-organic frameworks for advanced drug delivery // Acta Pharmaceutica Sinica B. — 2021. — Vol. 11, № 8. — P. 2362–2395. — URL: https://doi.org/10.1016/j.apsb.2021.03.019
@article{he2021metalorganic,
title = {{Metal-organic frameworks for advanced drug delivery}},
author = {Siyu He and Li Wu and Xue Li and Hongyu Sun and Ting Xiong and Jie Liu and Chengxi Huang and Huipeng Xu and Huimin Sun and Weidong Chen and Ruxandra Gref and Jiwen Zhang},
journal = {Acta Pharmaceutica Sinica B},
year = {2021},
volume = {11},
number = {8},
pages = {2362--2395},
doi = {10.1016/j.apsb.2021.03.019},
url = {https://doi.org/10.1016/j.apsb.2021.03.019}
}TY - JOUR AU - He, Siyu AU - Wu, Li AU - Li, Xue AU - Sun, Hongyu AU - Xiong, Ting AU - Liu, Jie AU - Huang, Chengxi AU - Xu, Huipeng AU - Sun, Huimin AU - Chen, Weidong AU - Gref, Ruxandra AU - Zhang, Jiwen TI - Metal-organic frameworks for advanced drug delivery JO - Acta Pharmaceutica Sinica B VL - 11 IS - 8 SP - 2362 EP - 2395 PY - 2021 DA - 2021/03/14 DO - 10.1016/j.apsb.2021.03.019 UR - https://doi.org/10.1016/j.apsb.2021.03.019 ER -
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