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Quangang Zhu, Zhongjian Chen, Pijush Kumar Paul, Yi Lü, Wei Wu, Jianping Qi
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastrointestinal (GI) tract and epithelia, the therapeutic PPs are usually administered by parenteral route. Given the big demand for oral administration in clinical use, a variety of researches focused on developing new technologies to overcome GI barriers of PPs, such as enteric coating, enzyme inhibitors, permeation enhancers, nanoparticles, as well as intestinal microdevices. Some new technologies have been developed under clinical trials and even on the market. This review summarizes the history, the physiological barriers and the overcoming approaches, current clinical and preclinical technologies, and future prospects of oral delivery of PPs.
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Zhu, Q., Chen, Z., Paul, P. K., Lü, Y., Wu, W., & Qi, J. (2021). Oral delivery of proteins and peptides: Challenges, status quo and future perspectives. Acta Pharmaceutica Sinica B, 11(8), 2416–2448. https://doi.org/10.1016/j.apsb.2021.04.001
Zhu, Quangang, et al. "Oral delivery of proteins and peptides: Challenges, status quo and future perspectives." Acta Pharmaceutica Sinica B, vol. 11, no. 8, 2021, pp. 2416–2448, https://doi.org/10.1016/j.apsb.2021.04.001.
Zhu, Quangang, Zhongjian Chen, Pijush Kumar Paul, Yi Lü, Wei Wu, and Jianping Qi. "Oral delivery of proteins and peptides: Challenges, status quo and future perspectives." Acta Pharmaceutica Sinica B 11, no. 8 (2021): 2416–2448. https://doi.org/10.1016/j.apsb.2021.04.001.
Zhu Q., Chen Z., Paul P. K. [и др.] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives // Acta Pharmaceutica Sinica B. — 2021. — Vol. 11, № 8. — P. 2416–2448. — URL: https://doi.org/10.1016/j.apsb.2021.04.001
@article{zhu2021oral,
title = {{Oral delivery of proteins and peptides: Challenges, status quo and future perspectives}},
author = {Quangang Zhu and Zhongjian Chen and Pijush Kumar Paul and Yi Lü and Wei Wu and Jianping Qi},
journal = {Acta Pharmaceutica Sinica B},
year = {2021},
volume = {11},
number = {8},
pages = {2416--2448},
doi = {10.1016/j.apsb.2021.04.001},
url = {https://doi.org/10.1016/j.apsb.2021.04.001}
}TY - JOUR AU - Zhu, Quangang AU - Chen, Zhongjian AU - Paul, Pijush Kumar AU - Lü, Yi AU - Wu, Wei AU - Qi, Jianping TI - Oral delivery of proteins and peptides: Challenges, status quo and future perspectives JO - Acta Pharmaceutica Sinica B VL - 11 IS - 8 SP - 2416 EP - 2448 PY - 2021 DA - 2021/04/29 DO - 10.1016/j.apsb.2021.04.001 UR - https://doi.org/10.1016/j.apsb.2021.04.001 ER -
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