One connector, four scholarly indexes, real DOIs and legal free PDFs. Works in Claude and ChatGPT.
Paste it into Claude or ChatGPT as a custom connector. 3-day free trial.
Bing Xie, Yaping Liu, Xiaotong Li, Pei Yang, Wei He
About 40% of approved drugs and nearly 90% of drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving the solubility and bioavailability of poorly water-soluble drugs is a critical issue that needs to be urgently addressed in drug development and application. This review briefly introduces the conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, and details the crystallization strategies, ionic liquids, and polymer-based, lipid-based, and inorganic-based carriers in improving solubility and bioavailability. Some of the most commonly used approved carrier materials for solubilization techniques are presented. Several approved poorly water-soluble drugs using solubilization techniques are summarized. Furthermore, this review summarizes the solubilization mechanism of each solubilization technique, reviews the latest research advances and challenges, and evaluates the potential for clinical translation. This review could guide the selection of a solubilization approach, dosage form, and administration route for poorly water-soluble drugs. Moreover, we discuss several promising solubilization techniques attracting increasing attention worldwide.
Formatted from the source metadata, not typed by hand. For a whole reference list, use the citation generator or ask your assistant through Find Research.
Xie, B., Liu, Y., Li, X., Yang, P., & He, W. (2024). Solubilization techniques used for poorly water-soluble drugs. Acta Pharmaceutica Sinica B, 14(11), 4683–4716. https://doi.org/10.1016/j.apsb.2024.08.027
Xie, Bing, et al. "Solubilization techniques used for poorly water-soluble drugs." Acta Pharmaceutica Sinica B, vol. 14, no. 11, 2024, pp. 4683–4716, https://doi.org/10.1016/j.apsb.2024.08.027.
Xie, Bing, Yaping Liu, Xiaotong Li, Pei Yang, and Wei He. "Solubilization techniques used for poorly water-soluble drugs." Acta Pharmaceutica Sinica B 14, no. 11 (2024): 4683–4716. https://doi.org/10.1016/j.apsb.2024.08.027.
Xie B., Liu Y., Li X. [и др.] Solubilization techniques used for poorly water-soluble drugs // Acta Pharmaceutica Sinica B. — 2024. — Vol. 14, № 11. — P. 4683–4716. — URL: https://doi.org/10.1016/j.apsb.2024.08.027
@article{xie2024solubilization,
title = {{Solubilization techniques used for poorly water-soluble drugs}},
author = {Bing Xie and Yaping Liu and Xiaotong Li and Pei Yang and Wei He},
journal = {Acta Pharmaceutica Sinica B},
year = {2024},
volume = {14},
number = {11},
pages = {4683--4716},
doi = {10.1016/j.apsb.2024.08.027},
url = {https://doi.org/10.1016/j.apsb.2024.08.027}
}TY - JOUR AU - Xie, Bing AU - Liu, Yaping AU - Li, Xiaotong AU - Yang, Pei AU - He, Wei TI - Solubilization techniques used for poorly water-soluble drugs JO - Acta Pharmaceutica Sinica B VL - 14 IS - 11 SP - 4683 EP - 4716 PY - 2024 DA - 2024/09/02 DO - 10.1016/j.apsb.2024.08.027 UR - https://doi.org/10.1016/j.apsb.2024.08.027 ER -
Add Find Research to Claude or ChatGPT and ask in plain language. The assistant reads this record, finds the papers around it and cites only what it actually found:
Setup takes about a minute: add the connector, then start the free trial.
Record from OpenAlex; open-access location from Unpaywall and the indexes. Find Research links only to legal copies.