- Published
- 2022-07-01
- Venue
- Cell, vol. 185, no. 14, pp. 2401-2421
- Cited by
- 3,084
- Open access
- Yes, hybrid
- DOI
- 10.1016/j.cell.2022.06.003
- PubMed
- 35803244
Abstract
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a broad set of biological contexts, from development to aging, immunity, and cancer. This review describes key regulators of this form of cell death within a framework of metabolism, ROS biology, and iron biology. Key concepts and major unanswered questions in the ferroptosis field are highlighted. The next decade promises to yield further breakthroughs in the mechanisms governing ferroptosis and additional ways of harnessing ferroptosis for therapeutic benefit.
Cite this paper
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- APA 7
Stockwell, B. R. (2022). Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. Cell, 185(14), 2401–2421. https://doi.org/10.1016/j.cell.2022.06.003
- MLA 9
Stockwell, Brent R. "Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications." Cell, vol. 185, no. 14, 2022, pp. 2401–2421, https://doi.org/10.1016/j.cell.2022.06.003.
- Chicago
Stockwell, Brent R. "Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications." Cell 185, no. 14 (2022): 2401–2421. https://doi.org/10.1016/j.cell.2022.06.003.
- GOST
Stockwell B. R. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications // Cell. — 2022. — Vol. 185, № 14. — P. 2401–2421. — URL: https://doi.org/10.1016/j.cell.2022.06.003
- BibTeX
@article{stockwell2022ferroptosis, title = {{Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications}}, author = {Brent R. Stockwell}, journal = {Cell}, year = {2022}, volume = {185}, number = {14}, pages = {2401--2421}, doi = {10.1016/j.cell.2022.06.003}, url = {https://doi.org/10.1016/j.cell.2022.06.003} }- RIS
TY - JOUR AU - Stockwell, Brent R. TI - Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications JO - Cell VL - 185 IS - 14 SP - 2401 EP - 2421 PY - 2022 DA - 2022/07/01 DO - 10.1016/j.cell.2022.06.003 UR - https://doi.org/10.1016/j.cell.2022.06.003 ER -