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Xue Chen, Ganglei Li, Qiuxian Zheng, Xinyu Gu, Qingmiao Shi, Yuanshuai Su, Qingfei Chu, Xin Yuan, Zhengyi Bao, Juan Lu, Lanjuan Li
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function. Emerging evidence supports an intimate relationship between Trp metabolism disorder and diseases. The levels or ratios of Trp metabolites are significantly associated with many clinical features. Additionally, studies have shown that disease progression can be controlled by modulating Trp metabolism. Indoleamine-2,3-dioxygenase, Trp-2,3-dioxygenase, kynurenine-3-monooxygenase, and Trp hydroxylase are the rate-limiting enzymes that are critical for Trp metabolism. These key regulatory enzymes can be targeted for treating several diseases, including tumors. These findings provide novel insights into the treatment of diseases. In this review, we have summarized the recent research progress on the role of Trp metabolites in health and disease along with their clinical applications.
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Chen, X., Li, G., Zheng, Q., Gu, X., Shi, Q., Su, Y., Chu, Q., Yuan, X., Bao, Z., Lu, J., & Li, L. (2023). Tryptophan metabolism in health and disease. Cell Metabolism, 35(8), 1304–1326. https://doi.org/10.1016/j.cmet.2023.06.004
Chen, Xue, et al. "Tryptophan metabolism in health and disease." Cell Metabolism, vol. 35, no. 8, 2023, pp. 1304–1326, https://doi.org/10.1016/j.cmet.2023.06.004.
Chen, Xue, Ganglei Li, Qiuxian Zheng, Xinyu Gu, Qingmiao Shi, Yuanshuai Su, Qingfei Chu, et al. "Tryptophan metabolism in health and disease." Cell Metabolism 35, no. 8 (2023): 1304–1326. https://doi.org/10.1016/j.cmet.2023.06.004.
Chen X., Li G., Zheng Q. [и др.] Tryptophan metabolism in health and disease // Cell Metabolism. — 2023. — Vol. 35, № 8. — P. 1304–1326. — URL: https://doi.org/10.1016/j.cmet.2023.06.004
@article{chen2023tryptophan,
title = {{Tryptophan metabolism in health and disease}},
author = {Xue Chen and Ganglei Li and Qiuxian Zheng and Xinyu Gu and Qingmiao Shi and Yuanshuai Su and Qingfei Chu and Xin Yuan and Zhengyi Bao and Juan Lu and Lanjuan Li},
journal = {Cell Metabolism},
year = {2023},
volume = {35},
number = {8},
pages = {1304--1326},
doi = {10.1016/j.cmet.2023.06.004},
url = {https://doi.org/10.1016/j.cmet.2023.06.004}
}TY - JOUR AU - Chen, Xue AU - Li, Ganglei AU - Zheng, Qiuxian AU - Gu, Xinyu AU - Shi, Qingmiao AU - Su, Yuanshuai AU - Chu, Qingfei AU - Yuan, Xin AU - Bao, Zhengyi AU - Lu, Juan AU - Li, Lanjuan TI - Tryptophan metabolism in health and disease JO - Cell Metabolism VL - 35 IS - 8 SP - 1304 EP - 1326 PY - 2023 DA - 2023/06/22 DO - 10.1016/j.cmet.2023.06.004 UR - https://doi.org/10.1016/j.cmet.2023.06.004 ER -
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