- Published
- 2021-01-01
- Venue
- Computational and Structural Biotechnology Journal, vol. 19, pp. 1335-1360
- Cited by
- 470
- Open access
- Yes, gold
- DOI
- 10.1016/j.csbj.2021.02.010
- PubMed
- 33777334
Abstract
The oralome is the summary of the dynamic interactions orchestrated between the ecological community of oral microorganisms (comprised of up to approximately 1000 species of bacteria, fungi, viruses, archaea and protozoa - the oral microbiome) that live in the oral cavity and the host. These microorganisms form a complex ecosystem that thrive in the dynamic oral environment in a symbiotic relationship with the human host. However, the microbial composition is significantly affected by interspecies and host-microbial interactions, which in turn, can impact the health and disease status of the host. In this review, we discuss the composition of the oralome and inter-species and host-microbial interactions that take place in the oral cavity and examine how these interactions change from healthy (eubiotic) to disease (dysbiotic) states. We further discuss the dysbiotic signatures associated with periodontitis and caries and their sequalae, (e.g., tooth/bone loss and pulpitis), and the systemic diseases associated with these oral diseases, such as infective endocarditis, atherosclerosis, diabetes, Alzheimer's disease and head and neck/oral cancer. We then discuss current computational techniques to assess dysbiotic oral microbiome changes. Lastly, we discuss current and novel techniques for modulation of the dysbiotic oral microbiome that may help in disease prevention and treatment, including standard hygiene methods, prebiotics, probiotics, use of nano-sized drug delivery systems (nano-DDS), extracellular polymeric matrix (EPM) disruption, and host response modulators.
Cite this paper
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- APA 7
Radaic, A., & Kapila, Y. L. (2021). The oralome and its dysbiosis: New insights into oral microbiome-host interactions. Computational and Structural Biotechnology Journal, 19, 1335–1360. https://doi.org/10.1016/j.csbj.2021.02.010
- MLA 9
Radaic, Allan, and Yvonne Lorraine Kapila. "The oralome and its dysbiosis: New insights into oral microbiome-host interactions." Computational and Structural Biotechnology Journal, vol. 19, 2021, pp. 1335–1360, https://doi.org/10.1016/j.csbj.2021.02.010.
- Chicago
Radaic, Allan, and Yvonne Lorraine Kapila. "The oralome and its dysbiosis: New insights into oral microbiome-host interactions." Computational and Structural Biotechnology Journal 19 (2021): 1335–1360. https://doi.org/10.1016/j.csbj.2021.02.010.
- GOST
Radaic A., Kapila Y. L. The oralome and its dysbiosis: New insights into oral microbiome-host interactions // Computational and Structural Biotechnology Journal. — 2021. — Vol. 19. — P. 1335–1360. — URL: https://doi.org/10.1016/j.csbj.2021.02.010
- BibTeX
@article{radaic2021oralome, title = {{The oralome and its dysbiosis: New insights into oral microbiome-host interactions}}, author = {Allan Radaic and Yvonne Lorraine Kapila}, journal = {Computational and Structural Biotechnology Journal}, year = {2021}, volume = {19}, pages = {1335--1360}, doi = {10.1016/j.csbj.2021.02.010}, url = {https://doi.org/10.1016/j.csbj.2021.02.010} }- RIS
TY - JOUR AU - Radaic, Allan AU - Kapila, Yvonne Lorraine TI - The oralome and its dysbiosis: New insights into oral microbiome-host interactions JO - Computational and Structural Biotechnology Journal VL - 19 SP - 1335 EP - 1360 PY - 2021 DA - 2021/01/01 DO - 10.1016/j.csbj.2021.02.010 UR - https://doi.org/10.1016/j.csbj.2021.02.010 ER -
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