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Minghui Li, Jing Gong, Lixiong Gao, Ting Zou, Jiahui Kang, Haiwei Xu
Tremendous progress has been made in the field of toxicology leading to the advance of developmental toxicity assessment. Conventional animal models and in vitro two-dimensional models cannot accurately describe toxic effects and predict actual in vivo responses due to obvious inter-species differences between humans and animals, as well as the lack of a physiologically relevant tissue microenvironment. Human embryonic stem cell (hESC)- and induced pluripotent stem cell (iPSC)-derived three-dimensional organoids are ideal complex and multicellular organotypic models, which are indispensable in recapitulating morphogenesis, cellular interactions, and molecular processes of early human organ development. Recently, human organoids have been used for drug discovery, chemical toxicity and safety in vitro assessment. This review discusses the recent advances in the use of human organoid models, (i.e., brain, retinal, cardiac, liver, kidney, lung, and intestinal organoid models) for developmental toxicity and teratogenicity assessment of distinct tissues/organs following exposure to pharmaceutical compounds, heavy metals, persistent organic pollutants, nanomaterials, and ambient air pollutants. Combining next-generation organoid models with innovative engineering technologies generates novel and powerful tools for developmental toxicity and teratogenicity assessment, and the rapid progress in this field is expected to continue.
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Li, M., Gong, J., Gao, L., Zou, T., Kang, J., & Xu, H. (2022). Advanced human developmental toxicity and teratogenicity assessment using human organoid models. Ecotoxicology and Environmental Safety, 235, 113429. https://doi.org/10.1016/j.ecoenv.2022.113429
Li, Minghui, et al. "Advanced human developmental toxicity and teratogenicity assessment using human organoid models." Ecotoxicology and Environmental Safety, vol. 235, 2022, pp. 113429, https://doi.org/10.1016/j.ecoenv.2022.113429.
Li, Minghui, Jing Gong, Lixiong Gao, Ting Zou, Jiahui Kang, and Haiwei Xu. "Advanced human developmental toxicity and teratogenicity assessment using human organoid models." Ecotoxicology and Environmental Safety 235 (2022): 113429. https://doi.org/10.1016/j.ecoenv.2022.113429.
Li M., Gong J., Gao L. [и др.] Advanced human developmental toxicity and teratogenicity assessment using human organoid models // Ecotoxicology and Environmental Safety. — 2022. — Vol. 235. — P. 113429. — URL: https://doi.org/10.1016/j.ecoenv.2022.113429
@article{li2022advanced,
title = {{Advanced human developmental toxicity and teratogenicity assessment using human organoid models}},
author = {Minghui Li and Jing Gong and Lixiong Gao and Ting Zou and Jiahui Kang and Haiwei Xu},
journal = {Ecotoxicology and Environmental Safety},
year = {2022},
volume = {235},
pages = {113429},
doi = {10.1016/j.ecoenv.2022.113429},
url = {https://doi.org/10.1016/j.ecoenv.2022.113429}
}TY - JOUR AU - Li, Minghui AU - Gong, Jing AU - Gao, Lixiong AU - Zou, Ting AU - Kang, Jiahui AU - Xu, Haiwei TI - Advanced human developmental toxicity and teratogenicity assessment using human organoid models JO - Ecotoxicology and Environmental Safety VL - 235 SP - 113429 PY - 2022 DA - 2022/03/21 DO - 10.1016/j.ecoenv.2022.113429 UR - https://doi.org/10.1016/j.ecoenv.2022.113429 ER -
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