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Uttpal Anand, Abhijit Dey, Arvind K. Singh Chandel, Rupa Sanyal, Amarnath Mishra, Devendra Kumar Pandey, Valentina De Falco, Arun Upadhyay, Ramesh J. L. Kandimalla, Anupama Chaudhary and 4 more
Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions of deaths every year. With the new understanding of the molecular mechanism(s) of disease progression, our knowledge about the disease is snowballing, leading to the evolution of many new therapeutic regimes and their successive trials. In the past few decades, various combinations of therapies have been proposed and are presently employed in the treatment of diverse cancers. Targeted drug therapy, immunotherapy, and personalized medicines are now largely being employed, which were not common a few years back. The field of cancer discoveries and therapeutics are evolving fast as cancer type-specific biomarkers are progressively being identified and several types of cancers are nowadays undergoing systematic therapies, extending patients' disease-free survival thereafter. Although growing evidence shows that a systematic and targeted approach could be the future of cancer medicine, chemotherapy remains a largely opted therapeutic option despite its known side effects on the patient's physical and psychological health. Chemotherapeutic agents/pharmaceuticals served a great purpose over the past few decades and have remained the frontline choice for advanced-stage malignancies where surgery and/or radiation therapy cannot be prescribed due to specific reasons. The present report succinctly reviews the existing and contemporary advancements in chemotherapy and assesses the status of the enrolled drugs/pharmaceuticals; it also comprehensively discusses the emerging role of specific/targeted therapeutic strategies that are presently being employed to achieve better clinical success/survival rate in cancer patients.
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Anand, U., Dey, A., Chandel, A. K. S., Sanyal, R., Mishra, A., Pandey, D. K., Falco, V. D., Upadhyay, A., Kandimalla, R. J. L., Chaudhary, A., Dhanjal, J. K., Dewanjee, S., Vallamkondu, J., & Lastra, J. M. P. D. L. (2022). Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics. Genes & Diseases, 10(4), 1367–1401. https://doi.org/10.1016/j.gendis.2022.02.007
Anand, Uttpal, et al. "Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics." Genes & Diseases, vol. 10, no. 4, 2022, pp. 1367–1401, https://doi.org/10.1016/j.gendis.2022.02.007.
Anand, Uttpal, Abhijit Dey, Arvind K. Singh Chandel, Rupa Sanyal, Amarnath Mishra, Devendra Kumar Pandey, Valentina De Falco, et al. "Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics." Genes & Diseases 10, no. 4 (2022): 1367–1401. https://doi.org/10.1016/j.gendis.2022.02.007.
Anand U., Dey A., Chandel A. K. S. [и др.] Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics // Genes & Diseases. — 2022. — Vol. 10, № 4. — P. 1367–1401. — URL: https://doi.org/10.1016/j.gendis.2022.02.007
@article{anand2022cancer,
title = {{Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics}},
author = {Uttpal Anand and Abhijit Dey and Arvind K. Singh Chandel and Rupa Sanyal and Amarnath Mishra and Devendra Kumar Pandey and Valentina De Falco and Arun Upadhyay and Ramesh J. L. Kandimalla and Anupama Chaudhary and Jaspreet Kaur Dhanjal and Saikat Dewanjee and Jayalakshmi Vallamkondu and José Manuel Pérez de la Lastra},
journal = {Genes \& Diseases},
year = {2022},
volume = {10},
number = {4},
pages = {1367--1401},
doi = {10.1016/j.gendis.2022.02.007},
url = {https://doi.org/10.1016/j.gendis.2022.02.007}
}TY - JOUR AU - Anand, Uttpal AU - Dey, Abhijit AU - Chandel, Arvind K. Singh AU - Sanyal, Rupa AU - Mishra, Amarnath AU - Pandey, Devendra Kumar AU - Falco, Valentina De AU - Upadhyay, Arun AU - Kandimalla, Ramesh J. L. AU - Chaudhary, Anupama AU - Dhanjal, Jaspreet Kaur AU - Dewanjee, Saikat AU - Vallamkondu, Jayalakshmi AU - Lastra, José Manuel Pérez de la TI - Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics JO - Genes & Diseases VL - 10 IS - 4 SP - 1367 EP - 1401 PY - 2022 DA - 2022/03/18 DO - 10.1016/j.gendis.2022.02.007 UR - https://doi.org/10.1016/j.gendis.2022.02.007 ER -
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