- Published
- 2022-06-09
- Venue
- Trends in Immunology, vol. 43, no. 7, pp. 546-563
- Cited by
- 701
- Open access
- Yes, hybrid
- DOI
- 10.1016/j.it.2022.04.008
- PubMed
- 35690521
Abstract
Tumor-associated macrophages (TAMs) have multiple potent functions in cancer and, thus, represent important therapeutic targets. These diverse functions highlight the heterogenous nature of TAMs. Recent single cell omics technologies have significantly advanced our understanding of the molecular diversity of TAMs. However, a unifying nomenclature of TAM diversity and annotation of their molecular signatures is lacking. Here, we review recent major studies of single cell transcriptome, epigenome, metabolome, and spatial omics of cancer with a specific focus on TAMs. We also propose a consensus model of TAM diversity and present avenues for future research.
Cite this paper
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- APA 7
Ma, R., Black, A., & Qian, B. (2022). Macrophage diversity in cancer revisited in the era of single-cell omics. Trends in Immunology, 43(7), 546–563. https://doi.org/10.1016/j.it.2022.04.008
- MLA 9
Ma, Ruoyu, et al. "Macrophage diversity in cancer revisited in the era of single-cell omics." Trends in Immunology, vol. 43, no. 7, 2022, pp. 546–563, https://doi.org/10.1016/j.it.2022.04.008.
- Chicago
Ma, Ruoyu, Annabel Black, and Bin‐Zhi Qian. "Macrophage diversity in cancer revisited in the era of single-cell omics." Trends in Immunology 43, no. 7 (2022): 546–563. https://doi.org/10.1016/j.it.2022.04.008.
- GOST
Ma R., Black A., Qian B. Macrophage diversity in cancer revisited in the era of single-cell omics // Trends in Immunology. — 2022. — Vol. 43, № 7. — P. 546–563. — URL: https://doi.org/10.1016/j.it.2022.04.008
- BibTeX
@article{ma2022macrophage, title = {{Macrophage diversity in cancer revisited in the era of single-cell omics}}, author = {Ruoyu Ma and Annabel Black and Bin‐Zhi Qian}, journal = {Trends in Immunology}, year = {2022}, volume = {43}, number = {7}, pages = {546--563}, doi = {10.1016/j.it.2022.04.008}, url = {https://doi.org/10.1016/j.it.2022.04.008} }- RIS
TY - JOUR AU - Ma, Ruoyu AU - Black, Annabel AU - Qian, Bin‐Zhi TI - Macrophage diversity in cancer revisited in the era of single-cell omics JO - Trends in Immunology VL - 43 IS - 7 SP - 546 EP - 563 PY - 2022 DA - 2022/06/09 DO - 10.1016/j.it.2022.04.008 UR - https://doi.org/10.1016/j.it.2022.04.008 ER -