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Nazeer Hussain Khan, Maria Mir, Lei Qian, Mahnoor Baloch, Muhammad Farhan Ali Khan, Asim Ur Rehman, Ebenezeri Erasto Ngowi, Dongdong Wu, Xin‐Ying Ji
Background: Skin cancer has been the leading type of cancer worldwide. Melanoma and non-melanoma skin cancers are now the most common types of skin cancer that have been reached to epidemic proportion. Based on the rapid prevalence of skin cancers, and lack of efficient drug delivery systems, it is essential to surge the possible ways to prevent or cure the disease. Aim of review: Although surgical modalities and therapies have been made great progress in recent years, however, there is still an urgent need to alleviate its increased burden. Hence, understanding the precise pathophysiological signaling mechanisms and all other factors of such skin insults will be beneficial for the development of more efficient therapies. Key scientific concepts of review: In this review, we explained new understandings about onset and development of skin cancer and described its management via polymeric micro/nano carriers-based therapies, highlighting the current key bottlenecks and future prospective in this field. In therapeutic drug/gene delivery approaches, polymeric carriers-based system is the most promising strategy. This review discusses that how polymers have successfully been exploited for development of micro/nanosized systems for efficient delivery of anticancer genes and drugs overcoming all the barriers and limitations associated with available conventional therapies. In addition to drug/gene delivery, intelligent polymeric nanocarriers platforms have also been established for combination anticancer therapies including photodynamic and photothermal, and for theranostic applications. This portfolio of latest approaches could promote the blooming growth of research and their clinical availability.
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Khan, N. H., Mir, M., Qian, L., Baloch, M., Khan, M. F. A., Rehman, A. U., Ngowi, E. E., Wu, D., & Ji, X. (2021). Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures. Journal of Advanced Research, 36, 223–247. https://doi.org/10.1016/j.jare.2021.06.014
Khan, Nazeer Hussain, et al. "Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures." Journal of Advanced Research, vol. 36, 2021, pp. 223–247, https://doi.org/10.1016/j.jare.2021.06.014.
Khan, Nazeer Hussain, Maria Mir, Lei Qian, Mahnoor Baloch, Muhammad Farhan Ali Khan, Asim Ur Rehman, Ebenezeri Erasto Ngowi, Dongdong Wu, and Xin‐Ying Ji. "Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures." Journal of Advanced Research 36 (2021): 223–247. https://doi.org/10.1016/j.jare.2021.06.014.
Khan N. H., Mir M., Qian L. [и др.] Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures // Journal of Advanced Research. — 2021. — Vol. 36. — P. 223–247. — URL: https://doi.org/10.1016/j.jare.2021.06.014
@article{khan2021skin,
title = {{Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures}},
author = {Nazeer Hussain Khan and Maria Mir and Lei Qian and Mahnoor Baloch and Muhammad Farhan Ali Khan and Asim Ur Rehman and Ebenezeri Erasto Ngowi and Dongdong Wu and Xin‐Ying Ji},
journal = {Journal of Advanced Research},
year = {2021},
volume = {36},
pages = {223--247},
doi = {10.1016/j.jare.2021.06.014},
url = {https://doi.org/10.1016/j.jare.2021.06.014}
}TY - JOUR AU - Khan, Nazeer Hussain AU - Mir, Maria AU - Qian, Lei AU - Baloch, Mahnoor AU - Khan, Muhammad Farhan Ali AU - Rehman, Asim Ur AU - Ngowi, Ebenezeri Erasto AU - Wu, Dongdong AU - Ji, Xin‐Ying TI - Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures JO - Journal of Advanced Research VL - 36 SP - 223 EP - 247 PY - 2021 DA - 2021/06/16 DO - 10.1016/j.jare.2021.06.014 UR - https://doi.org/10.1016/j.jare.2021.06.014 ER -
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