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Laura E. McCoubrey, Alessia Favaron, Atheer Awad, Mine Orlu, Simon Gaisford, Abdul W. Basit
Colonic drug delivery can facilitate access to unique therapeutic targets and has the potential to enhance drug bioavailability whilst reducing off-target effects. Delivering drugs to the colon requires considered formulation development, as both oral and rectal dosage forms can encounter challenges if the colon's distinct physiological environment is not appreciated. As the therapeutic opportunities surrounding colonic drug delivery multiply, the success of novel pharmaceuticals lies in their design. This review provides a modern insight into the key parameters determining the effective design and development of colon-targeted medicines. Influential physiological features governing the release, dissolution, stability, and absorption of drugs in the colon are first discussed, followed by an overview of the most reliable colon-targeted formulation strategies. Finally, the most appropriate in vitro, in vivo, and in silico preclinical investigations are presented, with the goal of inspiring strategic development of new colon-targeted therapeutics.
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McCoubrey, L. E., Favaron, A., Awad, A., Orlu, M., Gaisford, S., & Basit, A. W. (2022). Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics. Journal of Controlled Release, 353, 1107–1126. https://doi.org/10.1016/j.jconrel.2022.12.029
McCoubrey, Laura E., et al. "Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics." Journal of Controlled Release, vol. 353, 2022, pp. 1107–1126, https://doi.org/10.1016/j.jconrel.2022.12.029.
McCoubrey, Laura E., Alessia Favaron, Atheer Awad, Mine Orlu, Simon Gaisford, and Abdul W. Basit. "Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics." Journal of Controlled Release 353 (2022): 1107–1126. https://doi.org/10.1016/j.jconrel.2022.12.029.
McCoubrey L. E., Favaron A., Awad A. [и др.] Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics // Journal of Controlled Release. — 2022. — Vol. 353. — P. 1107–1126. — URL: https://doi.org/10.1016/j.jconrel.2022.12.029
@article{mccoubrey2022colonic,
title = {{Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics}},
author = {Laura E. McCoubrey and Alessia Favaron and Atheer Awad and Mine Orlu and Simon Gaisford and Abdul W. Basit},
journal = {Journal of Controlled Release},
year = {2022},
volume = {353},
pages = {1107--1126},
doi = {10.1016/j.jconrel.2022.12.029},
url = {https://doi.org/10.1016/j.jconrel.2022.12.029}
}TY - JOUR AU - McCoubrey, Laura E. AU - Favaron, Alessia AU - Awad, Atheer AU - Orlu, Mine AU - Gaisford, Simon AU - Basit, Abdul W. TI - Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics JO - Journal of Controlled Release VL - 353 SP - 1107 EP - 1126 PY - 2022 DA - 2022/12/24 DO - 10.1016/j.jconrel.2022.12.029 UR - https://doi.org/10.1016/j.jconrel.2022.12.029 ER -
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