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Adaeze Linda Onugwu, Chinekwu Sherridan Nwagwu, Sabastine Obinna Onugwu, Adaeze Chidiebere Echezona, Chinazom Precious Agbo, Stella Amarachi Ihim, Prosper Emeh, Petra Obioma Nnamani, Anthony Amaechi Attama, Vitaliy V. Khutoryanskiy
Diseases affecting the anterior segment of the eye are the primary causes of vision impairment and blindness globally. Drug administration through the topical ocular route is widely accepted because of its user/patient friendliness - ease of administration and convenience. However, it remains a significant challenge to efficiently deliver drugs to the eye through this route because of various structural and physiological constraints that restrict the distribution of therapeutic molecules into the ocular tissues. The bioavailability of topically applied ocular medications such as eye drops is typically less than 5%. Developing novel delivery systems to increase the retention time on the ocular surfaces and permeation through the cornea is one of the approaches adopted to boost the bioavailability of topically administered medications. Drug delivery systems based on nanotechnology such as micelles, nanosuspensions, nanoparticles, nanoemulsions, liposomes, dendrimers, niosomes, cubosomes and nanowafers have been investigated as effective alternatives to conventional ocular delivery systems in treating diseases of the anterior segment of the eye. This review discussed different nanotechnology-based delivery systems that are currently investigated for treating and managing diseases affecting the anterior ocular tissues. We also looked at the challenges in translating these systems into clinical use and the prospects of nanocarriers as a vehicle for the delivery of phytoactive compounds to the anterior segment of the eye.
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Onugwu, A. L., Nwagwu, C. S., Onugwu, S. O., Echezona, A. C., Agbo, C. P., Ihim, S. A., Emeh, P., Nnamani, P. O., Attama, A. A., & Khutoryanskiy, V. V. (2023). Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases. Journal of Controlled Release, 354, 465–488. https://doi.org/10.1016/j.jconrel.2023.01.018
Onugwu, Adaeze Linda, et al. "Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases." Journal of Controlled Release, vol. 354, 2023, pp. 465–488, https://doi.org/10.1016/j.jconrel.2023.01.018.
Onugwu, Adaeze Linda, Chinekwu Sherridan Nwagwu, Sabastine Obinna Onugwu, Adaeze Chidiebere Echezona, Chinazom Precious Agbo, Stella Amarachi Ihim, Prosper Emeh, Petra Obioma Nnamani, Anthony Amaechi Attama, and Vitaliy V. Khutoryanskiy. "Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases." Journal of Controlled Release 354 (2023): 465–488. https://doi.org/10.1016/j.jconrel.2023.01.018.
Onugwu A. L., Nwagwu C. S., Onugwu S. O. [и др.] Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases // Journal of Controlled Release. — 2023. — Vol. 354. — P. 465–488. — URL: https://doi.org/10.1016/j.jconrel.2023.01.018
@article{onugwu2023nanotechnology,
title = {{Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases}},
author = {Adaeze Linda Onugwu and Chinekwu Sherridan Nwagwu and Sabastine Obinna Onugwu and Adaeze Chidiebere Echezona and Chinazom Precious Agbo and Stella Amarachi Ihim and Prosper Emeh and Petra Obioma Nnamani and Anthony Amaechi Attama and Vitaliy V. Khutoryanskiy},
journal = {Journal of Controlled Release},
year = {2023},
volume = {354},
pages = {465--488},
doi = {10.1016/j.jconrel.2023.01.018},
url = {https://doi.org/10.1016/j.jconrel.2023.01.018}
}TY - JOUR AU - Onugwu, Adaeze Linda AU - Nwagwu, Chinekwu Sherridan AU - Onugwu, Sabastine Obinna AU - Echezona, Adaeze Chidiebere AU - Agbo, Chinazom Precious AU - Ihim, Stella Amarachi AU - Emeh, Prosper AU - Nnamani, Petra Obioma AU - Attama, Anthony Amaechi AU - Khutoryanskiy, Vitaliy V. TI - Nanotechnology based drug delivery systems for the treatment of anterior segment eye diseases JO - Journal of Controlled Release VL - 354 SP - 465 EP - 488 PY - 2023 DA - 2023/01/19 DO - 10.1016/j.jconrel.2023.01.018 UR - https://doi.org/10.1016/j.jconrel.2023.01.018 ER -
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