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Davide Francesco D'Amico, Pénélope A. Andreux, Pamela Valdés, Anurag Singh, Chris Rinsch, Johan H. Auwerx
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its impact on aging and disease been explored. UA enhances cellular health by increasing mitophagy and mitochondrial function and reducing detrimental inflammation. Several preclinical studies show how UA protects against aging and age-related conditions affecting muscle, brain, joints, and other organs. In humans, benefits of UA supplementation in the muscle are supported by recent clinical trials in elderly people. Here, we review the state of the art of UA's biology and its translational potential as a nutritional intervention in humans.
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D'Amico, D. F., Andreux, P. A., Valdés, P., Singh, A., Rinsch, C., & Auwerx, J. H. (2021). Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. Trends in Molecular Medicine, 27(7), 687–699. https://doi.org/10.1016/j.molmed.2021.04.009
D'Amico, Davide Francesco, et al. "Impact of the Natural Compound Urolithin A on Health, Disease, and Aging." Trends in Molecular Medicine, vol. 27, no. 7, 2021, pp. 687–699, https://doi.org/10.1016/j.molmed.2021.04.009.
D'Amico, Davide Francesco, Pénélope A. Andreux, Pamela Valdés, Anurag Singh, Chris Rinsch, and Johan H. Auwerx. "Impact of the Natural Compound Urolithin A on Health, Disease, and Aging." Trends in Molecular Medicine 27, no. 7 (2021): 687–699. https://doi.org/10.1016/j.molmed.2021.04.009.
D'Amico D. F., Andreux P. A., Valdés P. [и др.] Impact of the Natural Compound Urolithin A on Health, Disease, and Aging // Trends in Molecular Medicine. — 2021. — Vol. 27, № 7. — P. 687–699. — URL: https://doi.org/10.1016/j.molmed.2021.04.009
@article{damico2021impact,
title = {{Impact of the Natural Compound Urolithin A on Health, Disease, and Aging}},
author = {Davide Francesco D'Amico and Pénélope A. Andreux and Pamela Valdés and Anurag Singh and Chris Rinsch and Johan H. Auwerx},
journal = {Trends in Molecular Medicine},
year = {2021},
volume = {27},
number = {7},
pages = {687--699},
doi = {10.1016/j.molmed.2021.04.009},
url = {https://doi.org/10.1016/j.molmed.2021.04.009}
}TY - JOUR AU - D'Amico, Davide Francesco AU - Andreux, Pénélope A. AU - Valdés, Pamela AU - Singh, Anurag AU - Rinsch, Chris AU - Auwerx, Johan H. TI - Impact of the Natural Compound Urolithin A on Health, Disease, and Aging JO - Trends in Molecular Medicine VL - 27 IS - 7 SP - 687 EP - 699 PY - 2021 DA - 2021/05/21 DO - 10.1016/j.molmed.2021.04.009 UR - https://doi.org/10.1016/j.molmed.2021.04.009 ER -
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