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Brett J. Kagan, Andy C. Kitchen, Nhi Thao Tran, Forough Habibollahi, M. Amin Khajehnejad, Bradyn J. Parker, Anjali Bhat, Ben Rollo, Adeel Razi, Karl John Friston
Integrating neurons into digital systems may enable performance infeasible with silicon alone. Here, we develop DishBrain, a system that harnesses the inherent adaptive computation of neurons in a structured environment. In vitro neural networks from human or rodent origins are integrated with in silico computing via a high-density multielectrode array. Through electrophysiological stimulation and recording, cultures are embedded in a simulated game-world, mimicking the arcade game "Pong." Applying implications from the theory of active inference via the free energy principle, we find apparent learning within five minutes of real-time gameplay not observed in control conditions. Further experiments demonstrate the importance of closed-loop structured feedback in eliciting learning over time. Cultures display the ability to self-organize activity in a goal-directed manner in response to sparse sensory information about the consequences of their actions, which we term synthetic biological intelligence. Future applications may provide further insights into the cellular correlates of intelligence.
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Kagan, B. J., Kitchen, A. C., Tran, N. T., Habibollahi, F., Khajehnejad, M. A., Parker, B. J., Bhat, A., Rollo, B., Razi, A., & Friston, K. J. (2022). In vitro neurons learn and exhibit sentience when embodied in a simulated game-world. Neuron, 110(23), 3952–3969.e8. https://doi.org/10.1016/j.neuron.2022.09.001
Kagan, Brett J., et al. "In vitro neurons learn and exhibit sentience when embodied in a simulated game-world." Neuron, vol. 110, no. 23, 2022, pp. 3952–3969.e8, https://doi.org/10.1016/j.neuron.2022.09.001.
Kagan, Brett J., Andy C. Kitchen, Nhi Thao Tran, Forough Habibollahi, M. Amin Khajehnejad, Bradyn J. Parker, Anjali Bhat, Ben Rollo, Adeel Razi, and Karl John Friston. "In vitro neurons learn and exhibit sentience when embodied in a simulated game-world." Neuron 110, no. 23 (2022): 3952–3969.e8. https://doi.org/10.1016/j.neuron.2022.09.001.
Kagan B. J., Kitchen A. C., Tran N. T. [и др.] In vitro neurons learn and exhibit sentience when embodied in a simulated game-world // Neuron. — 2022. — Vol. 110, № 23. — P. 3952–3969.e8. — URL: https://doi.org/10.1016/j.neuron.2022.09.001
@article{kagan2022vitro,
title = {{In vitro neurons learn and exhibit sentience when embodied in a simulated game-world}},
author = {Brett J. Kagan and Andy C. Kitchen and Nhi Thao Tran and Forough Habibollahi and M. Amin Khajehnejad and Bradyn J. Parker and Anjali Bhat and Ben Rollo and Adeel Razi and Karl John Friston},
journal = {Neuron},
year = {2022},
volume = {110},
number = {23},
pages = {3952--3969.e8},
doi = {10.1016/j.neuron.2022.09.001},
url = {https://doi.org/10.1016/j.neuron.2022.09.001}
}TY - JOUR AU - Kagan, Brett J. AU - Kitchen, Andy C. AU - Tran, Nhi Thao AU - Habibollahi, Forough AU - Khajehnejad, M. Amin AU - Parker, Bradyn J. AU - Bhat, Anjali AU - Rollo, Ben AU - Razi, Adeel AU - Friston, Karl John TI - In vitro neurons learn and exhibit sentience when embodied in a simulated game-world JO - Neuron VL - 110 IS - 23 SP - 3952 EP - 3969.e8 PY - 2022 DA - 2022/10/12 DO - 10.1016/j.neuron.2022.09.001 UR - https://doi.org/10.1016/j.neuron.2022.09.001 ER -
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