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Susana Proença, Beate Isabella Escher, Fabian C. Fischer, Ciaran P. Fisher, Sebastien Grégoire, Nicky J. Hewitt, Beate Nicol, Alicia Paini, Nynke I. Kramer
Nominal effect concentrations from in vitro toxicity assays may lead to inaccurate estimations of in vivo toxic doses because the nominal concentration poorly reflects the concentration at the molecular target in cells in vitro, which is responsible for initiating effects and can be referred to as the biologically effective dose. Chemicals can differentially distribute between in vitro assay compartments, including serum constituents in exposure medium, microtitre plate plastic, headspace and extracellular matrices. The partitioning of test chemicals to these extracellular compartments reduces the concentration at the molecular target. Free concentrations in medium and cell-associated concentrations are considered better proxies of the biologically effective dose. This paper reviews the mechanisms by which test chemicals distribute between in vitro assay compartments, and also lists the physicochemical properties driving the extent of this distribution. The mechanisms and physicochemical properties driving the distribution of test chemical in vitro help explain the makeup of mass balance models that estimate free concentrations and cell-associated concentrations in in vitro toxicity assays. A thorough understanding of the distribution processes and assumptions underlying these mass balance models helps define chemical and biological applicability domains of individual models, as well as provide a perspective on how to improve model predictivity and quantitative in vitro-in vivo extrapolations.
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Proença, S., Escher, B. I., Fischer, F. C., Fisher, C. P., Grégoire, S., Hewitt, N. J., Nicol, B., Paini, A., & Kramer, N. I. (2021). Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models. Toxicology in Vitro, 73, 105133. https://doi.org/10.1016/j.tiv.2021.105133
Proença, Susana, et al. "Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models." Toxicology in Vitro, vol. 73, 2021, pp. 105133, https://doi.org/10.1016/j.tiv.2021.105133.
Proença, Susana, Beate Isabella Escher, Fabian C. Fischer, Ciaran P. Fisher, Sebastien Grégoire, Nicky J. Hewitt, Beate Nicol, Alicia Paini, and Nynke I. Kramer. "Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models." Toxicology in Vitro 73 (2021): 105133. https://doi.org/10.1016/j.tiv.2021.105133.
Proença S., Escher B. I., Fischer F. C. [и др.] Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models // Toxicology in Vitro. — 2021. — Vol. 73. — P. 105133. — URL: https://doi.org/10.1016/j.tiv.2021.105133
@article{proenca2021effective,
title = {{Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models}},
author = {Susana Proença and Beate Isabella Escher and Fabian C. Fischer and Ciaran P. Fisher and Sebastien Grégoire and Nicky J. Hewitt and Beate Nicol and Alicia Paini and Nynke I. Kramer},
journal = {Toxicology in Vitro},
year = {2021},
volume = {73},
pages = {105133},
doi = {10.1016/j.tiv.2021.105133},
url = {https://doi.org/10.1016/j.tiv.2021.105133}
}TY - JOUR AU - Proença, Susana AU - Escher, Beate Isabella AU - Fischer, Fabian C. AU - Fisher, Ciaran P. AU - Grégoire, Sebastien AU - Hewitt, Nicky J. AU - Nicol, Beate AU - Paini, Alicia AU - Kramer, Nynke I. TI - Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models JO - Toxicology in Vitro VL - 73 SP - 105133 PY - 2021 DA - 2021/03/01 DO - 10.1016/j.tiv.2021.105133 UR - https://doi.org/10.1016/j.tiv.2021.105133 ER -
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