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You Li, Xin Wang, Dianna M. Blau, Mauricio T. Caballero, Daniel R. Feikin, Christopher John Gill, Shabir Ahmed Madhi, Saad B. Omer, Eric A. F. Simões, Harry J. Campbell and 111 more
BACKGROUND: Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory infection in young children. We previously estimated that in 2015, 33·1 million episodes of RSV-associated acute lower respiratory infection occurred in children aged 0-60 months, resulting in a total of 118 200 deaths worldwide. Since then, several community surveillance studies have been done to obtain a more precise estimation of RSV associated community deaths. We aimed to update RSV-associated acute lower respiratory infection morbidity and mortality at global, regional, and national levels in children aged 0-60 months for 2019, with focus on overall mortality and narrower infant age groups that are targeted by RSV prophylactics in development. METHODS: In this systematic analysis, we expanded our global RSV disease burden dataset by obtaining new data from an updated search for papers published between Jan 1, 2017, and Dec 31, 2020, from MEDLINE, Embase, Global Health, CINAHL, Web of Science, LILACS, OpenGrey, CNKI, Wanfang, and ChongqingVIP. We also included unpublished data from RSV GEN collaborators. Eligible studies reported data for children aged 0-60 months with RSV as primary infection with acute lower respiratory infection in community settings, or acute lower respiratory infection necessitating hospital admission; reported data for at least 12 consecutive months, except for in-hospital case fatality ratio (CFR) or for where RSV seasonality is well-defined; and reported incidence rate, hospital admission rate, RSV positive proportion in acute lower respiratory infection hospital admission, or in-hospital CFR. Studies were excluded if case definition was not clearly defined or not consistently applied, RSV infection was not laboratory confirmed or based on serology alone, or if the report included fewer than 50 cases of acute lower respiratory infection. We applied a generalised linear mixed-effects model (GLMM) to estimate RSV-associated acute lower respiratory infection incidence, hospital admission, and in-hospital mortality both globally and regionally (by country development status and by World Bank Income Classification) in 2019. We estimated country-level RSV-associated acute lower respiratory infection incidence through a risk-factor based model. We developed new models (through GLMM) that incorporated the latest RSV community mortality data for estimating overall RSV mortality. This review was registered in PROSPERO (CRD42021252400). FINDINGS: In addition to 317 studies included in our previous review, we identified and included 113 new eligible studies and unpublished data from 51 studies, for a total of 481 studies. We estimated that globally in 2019, there were 33·0 million RSV-associated acute lower respiratory infection episodes (uncertainty range [UR] 25·4-44·6 million), 3·6 million RSV-associated acute lower respiratory infection hospital admissions (2·9-4·6 million), 26 300 RSV-associated acute lower respiratory infection in-hospital deaths (15 100-49 100), and 101 400 RSV-attributable overall deaths (84 500-125 200) in children aged 0-60 months. In infants aged 0-6 months, we estimated that there were 6·6 million RSV-associated acute lower respiratory infection episodes (4·6-9·7 million), 1·4 million RSV-associated acute lower respiratory infection hospital admissions (1·0-2·0 million), 13 300 RSV-associated acute lower respiratory infection in-hospital deaths (6800-28 100), and 45 700 RSV-attributable overall deaths (38 400-55 900). 2·0% of deaths in children aged 0-60 months (UR 1·6-2·4) and 3·6% of deaths in children aged 28 days to 6 months (3·0-4·4) were attributable to RSV. More than 95% of RSV-associated acute lower respiratory infection episodes and more than 97% of RSV-attributable deaths across all age bands were in low-income and middle-income countries (LMICs). INTERPRETATION: RSV contributes substantially to morbidity and mortality burden globally in children aged 0-60 months, especially during the first 6 months of life and in LMICs. We highlight the striking overall mortality burden of RSV disease worldwide, with one in every 50 deaths in children aged 0-60 months and one in every 28 deaths in children aged 28 days to 6 months attributable to RSV. For every RSV-associated acute lower respiratory infection in-hospital death, we estimate approximately three more deaths attributable to RSV in the community. RSV passive immunisation programmes targeting protection during the first 6 months of life could have a substantial effect on reducing RSV disease burden, although more data are needed to understand the implications of the potential age-shifts in peak RSV burden to older age when these are implemented. FUNDING: EU Innovative Medicines Initiative Respiratory Syncytial Virus Consortium in Europe (RESCEU).
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Li, Y., Wang, X., Blau, D. M., Caballero, M. T., Feikin, D. R., Gill, C. J., Madhi, S. A., Omer, S. B., Simões, E. A. F., Campbell, H. J., Pariente, A. B., Bardach, D., Bassat, Q., Casalegno, J., Chakhunashvili, G., Crawford, N. W., Danilenko, D., Do, L. A. H., Echavarría, M., … Nair, H. (2022). Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. The Lancet, 399(10340), 2047–2064. https://doi.org/10.1016/s0140-6736(22)00478-0
Li, You, et al. "Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis." The Lancet, vol. 399, no. 10340, 2022, pp. 2047–2064, https://doi.org/10.1016/s0140-6736(22)00478-0.
Li, You, Xin Wang, Dianna M. Blau, Mauricio T. Caballero, Daniel R. Feikin, Christopher John Gill, Shabir Ahmed Madhi, et al. "Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis." The Lancet 399, no. 10340 (2022): 2047–2064. https://doi.org/10.1016/s0140-6736(22)00478-0.
Li Y., Wang X., Blau D. M. [и др.] Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis // The Lancet. — 2022. — Vol. 399, № 10340. — P. 2047–2064. — URL: https://doi.org/10.1016/s0140-6736(22)00478-0
@article{li2022global,
title = {{Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis}},
author = {You Li and Xin Wang and Dianna M. Blau and Mauricio T. Caballero and Daniel R. Feikin and Christopher John Gill and Shabir Ahmed Madhi and Saad B. Omer and Eric A. F. Simões and Harry J. Campbell and Ana Bermejo Pariente and Darmaa Bardach and Quique Bassat and Jean‐Sébastien Casalegno and Giorgi Chakhunashvili and Nigel W. Crawford and Daria Danilenko and Lien Anh Ha Do and Marcela Echavarría and Angela S. de Gentile and Aubree L. Gordon and Terho Heikkinen and Q. Sue Huang and Sophie Jullien and Anand Krishnan and Eduardo Luis López and Joško Markić and Ainara Mira‐Iglesias and Hannah Catherine Moore and Jocelyn Moyes and Lawrence M Mwananyanda and D. James Nokes and F. Noordeen and Evangeline Obodai and Nandhini Palani and Candice Romero and Vahid Salimi and Ashish Satav and Euri Seo and Zakhar Shchomak and Rosalyn J. Singleton and Столяров Кирилл Александрович and Sonia Stoszek and Anne von Gottberg and Danielle F. Wurzel and Lay‐Myint Yoshida and Chee Fu Yung and Heather Joy Zar and Michael E. Abram and Jeroen Aerssens and Annette Alafaci and Ángel Balmaseda and Teresa Bandeira and Ian Barr and Ena Batinović and Philippe Beutels and Jinal N. Bhiman and Christopher C. Blyth and Louis Bont and Sara S. Bressler and Cheryl Cohen and Rachel Cohen and Anna‐Maria Costa and Rowena Crow and Andrew J. Daley and Duc-Anh Dang and Clarisse Demont and Christine Desnoyers and Javier Díez‐Domingo and Maduja V. M. Divarathna and Mignon du Plessis and Madeleine Edgoose and Fausto Martín Ferolla and Thea Kølsen Fischer and Amanuel Tesfay Gebremedhin and Carlo Giaquinto and Yves Gillet and Roger Hernandez and Côme Horvat and Étienne Javouhey and Irakli Karseladze and John Kubale and Rakesh Kumar and Bruno Lina and Florencia Lución and Rae P. MacGinty and Federico Martinón‐Torres and Alissa McMinn and Adam Meijer and Petra Milić and Adrian Morel and Kim Mulholland and Tuya Mungun and Nickson Murunga and Claire E. Newbern and Mark Patrick Nicol and John Kofi Odoom and Peter Openshaw and Dominique Ploin and Fernando P. Polack and Andrew John Pollard and Namrata Prasad and Joan Puig‐Barberà and Janine Reiche and Noelia Soledad Reyes and Bishoy Rizkalla and S. Satao and Ting Shi and Sujatha Sistla and Matthew Snape and Yanran Song and Giselle M. Soto and Forough Tavakoli and Michiko Toizumi and Naranzul Tsedenbal and Maarten van den Berge and Charlotte Vernhes and Claire von Mollendorf and Sibongile Walaza and Gregory J. Walker and Harish Nair},
journal = {The Lancet},
year = {2022},
volume = {399},
number = {10340},
pages = {2047--2064},
doi = {10.1016/s0140-6736(22)00478-0},
url = {https://doi.org/10.1016/s0140-6736(22)00478-0}
}TY - JOUR AU - Li, You AU - Wang, Xin AU - Blau, Dianna M. AU - Caballero, Mauricio T. AU - Feikin, Daniel R. AU - Gill, Christopher John AU - Madhi, Shabir Ahmed AU - Omer, Saad B. AU - Simões, Eric A. F. AU - Campbell, Harry J. AU - Pariente, Ana Bermejo AU - Bardach, Darmaa AU - Bassat, Quique AU - Casalegno, Jean‐Sébastien AU - Chakhunashvili, Giorgi AU - Crawford, Nigel W. AU - Danilenko, Daria AU - Do, Lien Anh Ha AU - Echavarría, Marcela AU - Gentile, Angela S. de AU - Gordon, Aubree L. AU - Heikkinen, Terho AU - Huang, Q. Sue AU - Jullien, Sophie AU - Krishnan, Anand AU - López, Eduardo Luis AU - Markić, Joško AU - Mira‐Iglesias, Ainara AU - Moore, Hannah Catherine AU - Moyes, Jocelyn AU - Mwananyanda, Lawrence M AU - Nokes, D. James AU - Noordeen, F. AU - Obodai, Evangeline AU - Palani, Nandhini AU - Romero, Candice AU - Salimi, Vahid AU - Satav, Ashish AU - Seo, Euri AU - Shchomak, Zakhar AU - Singleton, Rosalyn J. AU - Александрович, Столяров Кирилл AU - Stoszek, Sonia AU - Gottberg, Anne von AU - Wurzel, Danielle F. AU - Yoshida, Lay‐Myint AU - Yung, Chee Fu AU - Zar, Heather Joy AU - Abram, Michael E. AU - Aerssens, Jeroen AU - Alafaci, Annette AU - Balmaseda, Ángel AU - Bandeira, Teresa AU - Barr, Ian AU - Batinović, Ena AU - Beutels, Philippe AU - Bhiman, Jinal N. AU - Blyth, Christopher C. AU - Bont, Louis AU - Bressler, Sara S. AU - Cohen, Cheryl AU - Cohen, Rachel AU - Costa, Anna‐Maria AU - Crow, Rowena AU - Daley, Andrew J. AU - Dang, Duc-Anh AU - Demont, Clarisse AU - Desnoyers, Christine AU - Díez‐Domingo, Javier AU - Divarathna, Maduja V. M. AU - Plessis, Mignon du AU - Edgoose, Madeleine AU - Ferolla, Fausto Martín AU - Fischer, Thea Kølsen AU - Gebremedhin, Amanuel Tesfay AU - Giaquinto, Carlo AU - Gillet, Yves AU - Hernandez, Roger AU - Horvat, Côme AU - Javouhey, Étienne AU - Karseladze, Irakli AU - Kubale, John AU - Kumar, Rakesh AU - Lina, Bruno AU - Lución, Florencia AU - MacGinty, Rae P. AU - Martinón‐Torres, Federico AU - McMinn, Alissa AU - Meijer, Adam AU - Milić, Petra AU - Morel, Adrian AU - Mulholland, Kim AU - Mungun, Tuya AU - Murunga, Nickson AU - Newbern, Claire E. AU - Nicol, Mark Patrick AU - Odoom, John Kofi AU - Openshaw, Peter AU - Ploin, Dominique AU - Polack, Fernando P. AU - Pollard, Andrew John AU - Prasad, Namrata AU - Puig‐Barberà, Joan AU - Reiche, Janine AU - Reyes, Noelia Soledad AU - Rizkalla, Bishoy AU - Satao, S. AU - Shi, Ting AU - Sistla, Sujatha AU - Snape, Matthew AU - Song, Yanran AU - Soto, Giselle M. AU - Tavakoli, Forough AU - Toizumi, Michiko AU - Tsedenbal, Naranzul AU - Berge, Maarten van den AU - Vernhes, Charlotte AU - Mollendorf, Claire von AU - Walaza, Sibongile AU - Walker, Gregory J. AU - Nair, Harish TI - Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis JO - The Lancet VL - 399 IS - 10340 SP - 2047 EP - 2064 PY - 2022 DA - 2022/05/01 DO - 10.1016/s0140-6736(22)00478-0 UR - https://doi.org/10.1016/s0140-6736(22)00478-0 ER -
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