One connector, four scholarly indexes, real DOIs and legal free PDFs. Works in Claude and ChatGPT.
Paste it into Claude or ChatGPT as a custom connector. 3-day free trial.
Hugh Adler, Susan Gould, Paul Hine, Luke B. Snell, Waison Wong, Catherine F. Houlihan, Jane C. Osborne, Tommy Rampling, Mike Beadsworth, Christopher James Arthur Duncan and 129 more
BACKGROUND: Cases of human monkeypox are rarely seen outside of west and central Africa. There are few data regarding viral kinetics or the duration of viral shedding and no licensed treatments. Two oral drugs, brincidofovir and tecovirimat, have been approved for treatment of smallpox and have demonstrated efficacy against monkeypox in animals. Our aim was to describe the longitudinal clinical course of monkeypox in a high-income setting, coupled with viral dynamics, and any adverse events related to novel antiviral therapies. METHODS: In this retrospective observational study, we report the clinical features, longitudinal virological findings, and response to off-label antivirals in seven patients with monkeypox who were diagnosed in the UK between 2018 and 2021, identified through retrospective case-note review. This study included all patients who were managed in dedicated high consequence infectious diseases (HCID) centres in Liverpool, London, and Newcastle, coordinated via a national HCID network. FINDINGS: We reviewed all cases since the inception of the HCID (airborne) network between Aug 15, 2018, and Sept 10, 2021, identifying seven patients. Of the seven patients, four were men and three were women. Three acquired monkeypox in the UK: one patient was a health-care worker who acquired the virus nosocomially, and one patient who acquired the virus abroad transmitted it to an adult and child within their household cluster. Notable disease features included viraemia, prolonged monkeypox virus DNA detection in upper respiratory tract swabs, reactive low mood, and one patient had a monkeypox virus PCR-positive deep tissue abscess. Five patients spent more than 3 weeks (range 22-39 days) in isolation due to prolonged PCR positivity. Three patients were treated with brincidofovir (200 mg once a week orally), all of whom developed elevated liver enzymes resulting in cessation of therapy. One patient was treated with tecovirimat (600 mg twice daily for 2 weeks orally), experienced no adverse effects, and had a shorter duration of viral shedding and illness (10 days hospitalisation) compared with the other six patients. One patient experienced a mild relapse 6 weeks after hospital discharge. INTERPRETATION: Human monkeypox poses unique challenges, even to well resourced health-care systems with HCID networks. Prolonged upper respiratory tract viral DNA shedding after skin lesion resolution challenged current infection prevention and control guidance. There is an urgent need for prospective studies of antivirals for this disease. FUNDING: None.
Formatted from the source metadata, not typed by hand. For a whole reference list, use the citation generator or ask your assistant through Find Research.
Adler, H., Gould, S., Hine, P., Snell, L. B., Wong, W., Houlihan, C. F., Osborne, J. C., Rampling, T., Beadsworth, M., Duncan, C. J. A., Dunning, J. W., Fletcher, T. E., Hunter, E., Jacobs, M., Khoo, S., Newsholme, W., Porter, D., Porter, R., Ratcliffe, L., … Hruby, D. E. (2022). Clinical features and management of human monkeypox: a retrospective observational study in the UK. The Lancet Infectious Diseases, 22(8), 1153–1162. https://doi.org/10.1016/s1473-3099(22)00228-6
Adler, Hugh, et al. "Clinical features and management of human monkeypox: a retrospective observational study in the UK." The Lancet Infectious Diseases, vol. 22, no. 8, 2022, pp. 1153–1162, https://doi.org/10.1016/s1473-3099(22)00228-6.
Adler, Hugh, Susan Gould, Paul Hine, Luke B. Snell, Waison Wong, Catherine F. Houlihan, Jane C. Osborne, et al. "Clinical features and management of human monkeypox: a retrospective observational study in the UK." The Lancet Infectious Diseases 22, no. 8 (2022): 1153–1162. https://doi.org/10.1016/s1473-3099(22)00228-6.
Adler H., Gould S., Hine P. [и др.] Clinical features and management of human monkeypox: a retrospective observational study in the UK // The Lancet Infectious Diseases. — 2022. — Vol. 22, № 8. — P. 1153–1162. — URL: https://doi.org/10.1016/s1473-3099(22)00228-6
@article{adler2022clinical,
title = {{Clinical features and management of human monkeypox: a retrospective observational study in the UK}},
author = {Hugh Adler and Susan Gould and Paul Hine and Luke B. Snell and Waison Wong and Catherine F. Houlihan and Jane C. Osborne and Tommy Rampling and Mike Beadsworth and Christopher James Arthur Duncan and Jake W Dunning and Tom E. Fletcher and Ewan Hunter and Michael Jacobs and Saye Khoo and William Newsholme and David Porter and Robert Porter and Libuše Ratcliffe and Matthias Ludwig Schmid and Malcolm Gracie Semple and Anne J. Tunbridge and Tom Wingfield and Nicholas M. Price and Mike Abouyannis and Asma Al-Balushi and Stephen Aston and Robert Ball and Nicholas J. Beeching and Thomas J Blanchard and Ffion Carlin and Geraint Davies and Angela Gillespie and Scott Rory Hicks and Marie-Claire Hoyle and Chinenye Ilozue and Luke Mair and Suzanne Marshall and Anne Neary and Emmanuel Fru Nsutebu and Samantha Parker and Hannah Ryan and Lance C. W. Turtle and Chris Smith and Jon Jurriaan van Aartsen and Naomi F. Walker and Stephen Woolley and Anu Chawla and Ian R. Hart and Anna Smielewska and Elizabeth C. Joekes and Cathryn Benson and Cheryl Brindley and Urmi Das and Chin-Kien Eyton-Chong and Claire Gnanalingham and Clare P. Halfhide and Beatriz Larrú and Sarah J. Mayell and Joanna McBride and Claire Oliver and Princy Paul and Andrew I Riordan and Lekha Sridhar and Megan Storey and Audrey Abdul and Jennifer Abrahamsen and Breda Athan and Sanjay R. Bhagani and Colin Stewart Brown and Oliver Carpenter and Ian M Cropley and Kerrie Frost and Susan Hopkins and Jessica Joyce and Lucy Lamb and Adrian Lyons and Tabitha W. Mahungu and Stephen Mepham and Edina Mukwaira and Alison J. Rodger and Caroline Taylor and Simon Warren and Alan Williams and Debbie Levitt and Denise Allen and Jill Dixon and Adam Evans and Pauline McNicholas and Brendan A. I. Payne and David Price and Uli Schwab and Allison Sykes and Yusri Taha and Margaret Ward and Marieke Emonts and Stephen Owens and Alina Botgros and Sam T Douthwaite and Anna L. Goodman and Akish Luintel and Eithne M.E. MacMahon and Gaia Nebbia and Geraldine A. O’Hara and Joseph Parsons and Ashwin Delmonte Sen and Daniel Stevenson and Tadgh Sullivan and Usman Taj and Claire van Nispen tot Pannerden and Helen Winslow and Ewa Zatyka and Ekene Alozie-Otuka and Csaba Beviz and Yusupha Ceesay and Latchmin Gargee and Morloh Kabia and Hannah J Mitchell and Shona Perkins and Mingaile Sasson and Kamal Sehmbey and Federico Tabios and Neil Wigglesworth and Emma Aarons and Tim J G Brooks and Matthew Dryden and Jenna Furneaux and Barry Gibney and Jennifer Small and Elizabeth J Truelove and Clare E. Warrell and Richard Firth and Gemma Hobson and Christopher Johnson and Alison Dewynter and Sebastian Nixon and Oliver Spence and Joachim J. Bugert and Dennis E. Hruby},
journal = {The Lancet Infectious Diseases},
year = {2022},
volume = {22},
number = {8},
pages = {1153--1162},
doi = {10.1016/s1473-3099(22)00228-6},
url = {https://doi.org/10.1016/s1473-3099(22)00228-6}
}TY - JOUR AU - Adler, Hugh AU - Gould, Susan AU - Hine, Paul AU - Snell, Luke B. AU - Wong, Waison AU - Houlihan, Catherine F. AU - Osborne, Jane C. AU - Rampling, Tommy AU - Beadsworth, Mike AU - Duncan, Christopher James Arthur AU - Dunning, Jake W AU - Fletcher, Tom E. AU - Hunter, Ewan AU - Jacobs, Michael AU - Khoo, Saye AU - Newsholme, William AU - Porter, David AU - Porter, Robert AU - Ratcliffe, Libuše AU - Schmid, Matthias Ludwig AU - Semple, Malcolm Gracie AU - Tunbridge, Anne J. AU - Wingfield, Tom AU - Price, Nicholas M. AU - Abouyannis, Mike AU - Al-Balushi, Asma AU - Aston, Stephen AU - Ball, Robert AU - Beeching, Nicholas J. AU - Blanchard, Thomas J AU - Carlin, Ffion AU - Davies, Geraint AU - Gillespie, Angela AU - Hicks, Scott Rory AU - Hoyle, Marie-Claire AU - Ilozue, Chinenye AU - Mair, Luke AU - Marshall, Suzanne AU - Neary, Anne AU - Nsutebu, Emmanuel Fru AU - Parker, Samantha AU - Ryan, Hannah AU - Turtle, Lance C. W. AU - Smith, Chris AU - Aartsen, Jon Jurriaan van AU - Walker, Naomi F. AU - Woolley, Stephen AU - Chawla, Anu AU - Hart, Ian R. AU - Smielewska, Anna AU - Joekes, Elizabeth C. AU - Benson, Cathryn AU - Brindley, Cheryl AU - Das, Urmi AU - Eyton-Chong, Chin-Kien AU - Gnanalingham, Claire AU - Halfhide, Clare P. AU - Larrú, Beatriz AU - Mayell, Sarah J. AU - McBride, Joanna AU - Oliver, Claire AU - Paul, Princy AU - Riordan, Andrew I AU - Sridhar, Lekha AU - Storey, Megan AU - Abdul, Audrey AU - Abrahamsen, Jennifer AU - Athan, Breda AU - Bhagani, Sanjay R. AU - Brown, Colin Stewart AU - Carpenter, Oliver AU - Cropley, Ian M AU - Frost, Kerrie AU - Hopkins, Susan AU - Joyce, Jessica AU - Lamb, Lucy AU - Lyons, Adrian AU - Mahungu, Tabitha W. AU - Mepham, Stephen AU - Mukwaira, Edina AU - Rodger, Alison J. AU - Taylor, Caroline AU - Warren, Simon AU - Williams, Alan AU - Levitt, Debbie AU - Allen, Denise AU - Dixon, Jill AU - Evans, Adam AU - McNicholas, Pauline AU - Payne, Brendan A. I. AU - Price, David AU - Schwab, Uli AU - Sykes, Allison AU - Taha, Yusri AU - Ward, Margaret AU - Emonts, Marieke AU - Owens, Stephen AU - Botgros, Alina AU - Douthwaite, Sam T AU - Goodman, Anna L. AU - Luintel, Akish AU - MacMahon, Eithne M.E. AU - Nebbia, Gaia AU - O’Hara, Geraldine A. AU - Parsons, Joseph AU - Sen, Ashwin Delmonte AU - Stevenson, Daniel AU - Sullivan, Tadgh AU - Taj, Usman AU - Pannerden, Claire van Nispen tot AU - Winslow, Helen AU - Zatyka, Ewa AU - Alozie-Otuka, Ekene AU - Beviz, Csaba AU - Ceesay, Yusupha AU - Gargee, Latchmin AU - Kabia, Morloh AU - Mitchell, Hannah J AU - Perkins, Shona AU - Sasson, Mingaile AU - Sehmbey, Kamal AU - Tabios, Federico AU - Wigglesworth, Neil AU - Aarons, Emma AU - Brooks, Tim J G AU - Dryden, Matthew AU - Furneaux, Jenna AU - Gibney, Barry AU - Small, Jennifer AU - Truelove, Elizabeth J AU - Warrell, Clare E. AU - Firth, Richard AU - Hobson, Gemma AU - Johnson, Christopher AU - Dewynter, Alison AU - Nixon, Sebastian AU - Spence, Oliver AU - Bugert, Joachim J. AU - Hruby, Dennis E. TI - Clinical features and management of human monkeypox: a retrospective observational study in the UK JO - The Lancet Infectious Diseases VL - 22 IS - 8 SP - 1153 EP - 1162 PY - 2022 DA - 2022/05/24 DO - 10.1016/s1473-3099(22)00228-6 UR - https://doi.org/10.1016/s1473-3099(22)00228-6 ER -
Add Find Research to Claude or ChatGPT and ask in plain language. The assistant reads this record, finds the papers around it and cites only what it actually found:
Setup takes about a minute: add the connector, then start the free trial.
Record from OpenAlex; open-access location from Unpaywall and the indexes. Find Research links only to legal copies.