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John Joseph McGrath, John J McGrath, Ali Al-Hamzawi, Jordi Alonso, Yasmin Altwaijri, Laura H Andrade, Evelyn J Bromet, Ronny Bruffaerts, José Miguel Caldas de Almeida, Stephanie Chardoul and 78 more
BACKGROUND: Information on the frequency and timing of mental disorder onsets across the lifespan is of fundamental importance for public health planning. Broad, cross-national estimates of this information from coordinated general population surveys were last updated in 2007. We aimed to provide updated and improved estimates of age-of-onset distributions, lifetime prevalence, and morbid risk. METHODS: In this cross-national analysis, we analysed data from respondents aged 18 years or older to the World Mental Health surveys, a coordinated series of cross-sectional, face-to-face community epidemiological surveys administered between 2001 and 2022. In the surveys, the WHO Composite International Diagnostic Interview, a fully structured psychiatric diagnostic interview, was used to assess age of onset, lifetime prevalence, and morbid risk of 13 DSM-IV mental disorders until age 75 years across surveys by sex. We did not assess ethnicity. The surveys were geographically clustered and weighted to adjust for selection probability, and standard errors of incidence rates and cumulative incidence curves were calculated using the jackknife repeated replications simulation method, taking weighting and geographical clustering of data into account. FINDINGS: We included 156 331 respondents from 32 surveys in 29 countries, including 12 low-income and middle-income countries and 17 high-income countries, and including 85 308 (54·5%) female respondents and 71 023 (45·4%) male respondents. The lifetime prevalence of any mental disorder was 28·6% (95% CI 27·9-29·2) for male respondents and 29·8% (29·2-30·3) for female respondents. Morbid risk of any mental disorder by age 75 years was 46·4% (44·9-47·8) for male respondents and 53·1% (51·9-54·3) for female respondents. Conditional probabilities of first onset peaked at approximately age 15 years, with a median age of onset of 19 years (IQR 14-32) for male respondents and 20 years (12-36) for female respondents. The two most prevalent disorders were alcohol use disorder and major depressive disorder for male respondents and major depressive disorder and specific phobia for female respondents. INTERPRETATION: By age 75 years, approximately half the population can expect to develop one or more of the 13 mental disorders considered in this Article. These disorders typically first emerge in childhood, adolescence, or young adulthood. Services should have the capacity to detect and treat common mental disorders promptly and to optimise care that suits people at these crucial parts of the life course. FUNDING: None.
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McGrath, J. J., McGrath, J. J., Al-Hamzawi, A., Alonso, J., Altwaijri, Y., Andrade, L. H., Bromet, E. J., Bruffaerts, R., Almeida, J. M. C. D., Chardoul, S., Chiu, W. T., Degenhardt, L. J., Demler, O., Ferry, F. R., Gureje, O., Haro, J. M., Karam, E. G., Karam, G., Khaled, S. M., … Zaslavsky, A. M. (2023). Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries. The Lancet Psychiatry, 10(9), 668–681. https://doi.org/10.1016/s2215-0366(23)00193-1
McGrath, John Joseph, et al. "Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries." The Lancet Psychiatry, vol. 10, no. 9, 2023, pp. 668–681, https://doi.org/10.1016/s2215-0366(23)00193-1.
McGrath, John Joseph, John J McGrath, Ali Al-Hamzawi, Jordi Alonso, Yasmin Altwaijri, Laura H Andrade, Evelyn J Bromet, et al. "Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries." The Lancet Psychiatry 10, no. 9 (2023): 668–681. https://doi.org/10.1016/s2215-0366(23)00193-1.
McGrath J. J., McGrath J. J., Al-Hamzawi A. [и др.] Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries // The Lancet Psychiatry. — 2023. — Vol. 10, № 9. — P. 668–681. — URL: https://doi.org/10.1016/s2215-0366(23)00193-1
@article{mcgrath2023onset,
title = {{Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries}},
author = {John Joseph McGrath and John J McGrath and Ali Al-Hamzawi and Jordi Alonso and Yasmin Altwaijri and Laura H Andrade and Evelyn J Bromet and Ronny Bruffaerts and José Miguel Caldas de Almeida and Stephanie Chardoul and Wai Tat Chiu and Louisa J Degenhardt and Olga Demler and Finola R. Ferry and Oye Gureje and Josep Maria Haro and Elie G Karam and Georges Karam and Salma Mawfek Khaled and Viviane Kovess–Masféty and Marta Magno and Maria Elena Medina-Mora and Jacek Moskalewicz and Fernando Navarro-Mateu and Daisuke Nishi and Oleguer Plana‐Ripoll and José Posada-Villa and Charlene M. Rapsey and Nancy A. Sampson and Juan Carlos Stagnaro and Dan J Stein and Margreet ten Have and Yolanda Torres and Cristian Vladescu and Peter W R Woodruff and Zahari Zarkov and Ronald C. Kessler and Sergio Aguilar-Gaxiola and Ali Al-Hamzawi and Jordi Alonso and Yasmin A. Altwaijri and Laura Helena Andrade and Lukoye Atwoli and Corina L. Benjet and Evelyn J. Bromet and Ronny Bruffaerts and Brendan Bunting and José Miguel Caldas-de-Almeida and Graça Cardoso and Stephanie Chardoul and Alfredo H. Cía and Louisa J Degenhardt and Giovanni de Girolamo and Oye Gureje and Josep Maria Haro and Meredith Harris and Hristo Ruskov Hinkov and Chiyi Hu and Peter de Jonge and Elie Georges Karam and Elie G. Karam and Georges Karam and Alan E. Kazdin and Norito Kawakami and Ronald C. Kessler and Andrzej Kiejna and Viviane Kovess–Masféty and John Joseph McGrath and John Joseph McGrath and Maria Elena Medina-Mora and Jacek Moskalewicz and Fernando Navarro-Mateu and Daisuke Nishi and Marina Piazza and José Posada-Villa and Kate Margaret Scott and Juan Carlos Stagnaro and Dan J. Stein and Margreet Ten Have and Yolanda Torres and María Carmen Viana and Daniel Vigo and Cristian Vladescu and David R. Williams and Peter W R Woodruff and Bogdan Wojtyniak and Miguel Xavier and Alan M. Zaslavsky},
journal = {The Lancet Psychiatry},
year = {2023},
volume = {10},
number = {9},
pages = {668--681},
doi = {10.1016/s2215-0366(23)00193-1},
url = {https://doi.org/10.1016/s2215-0366(23)00193-1}
}TY - JOUR AU - McGrath, John Joseph AU - McGrath, John J AU - Al-Hamzawi, Ali AU - Alonso, Jordi AU - Altwaijri, Yasmin AU - Andrade, Laura H AU - Bromet, Evelyn J AU - Bruffaerts, Ronny AU - Almeida, José Miguel Caldas de AU - Chardoul, Stephanie AU - Chiu, Wai Tat AU - Degenhardt, Louisa J AU - Demler, Olga AU - Ferry, Finola R. AU - Gureje, Oye AU - Haro, Josep Maria AU - Karam, Elie G AU - Karam, Georges AU - Khaled, Salma Mawfek AU - Kovess–Masféty, Viviane AU - Magno, Marta AU - Medina-Mora, Maria Elena AU - Moskalewicz, Jacek AU - Navarro-Mateu, Fernando AU - Nishi, Daisuke AU - Plana‐Ripoll, Oleguer AU - Posada-Villa, José AU - Rapsey, Charlene M. AU - Sampson, Nancy A. AU - Stagnaro, Juan Carlos AU - Stein, Dan J AU - Have, Margreet ten AU - Torres, Yolanda AU - Vladescu, Cristian AU - Woodruff, Peter W R AU - Zarkov, Zahari AU - Kessler, Ronald C. AU - Aguilar-Gaxiola, Sergio AU - Al-Hamzawi, Ali AU - Alonso, Jordi AU - Altwaijri, Yasmin A. AU - Andrade, Laura Helena AU - Atwoli, Lukoye AU - Benjet, Corina L. AU - Bromet, Evelyn J. AU - Bruffaerts, Ronny AU - Bunting, Brendan AU - Caldas-de-Almeida, José Miguel AU - Cardoso, Graça AU - Chardoul, Stephanie AU - Cía, Alfredo H. AU - Degenhardt, Louisa J AU - Girolamo, Giovanni de AU - Gureje, Oye AU - Haro, Josep Maria AU - Harris, Meredith AU - Hinkov, Hristo Ruskov AU - Hu, Chiyi AU - Jonge, Peter de AU - Karam, Elie Georges AU - Karam, Elie G. AU - Karam, Georges AU - Kazdin, Alan E. AU - Kawakami, Norito AU - Kessler, Ronald C. AU - Kiejna, Andrzej AU - Kovess–Masféty, Viviane AU - McGrath, John Joseph AU - McGrath, John Joseph AU - Medina-Mora, Maria Elena AU - Moskalewicz, Jacek AU - Navarro-Mateu, Fernando AU - Nishi, Daisuke AU - Piazza, Marina AU - Posada-Villa, José AU - Scott, Kate Margaret AU - Stagnaro, Juan Carlos AU - Stein, Dan J. AU - Have, Margreet Ten AU - Torres, Yolanda AU - Viana, María Carmen AU - Vigo, Daniel AU - Vladescu, Cristian AU - Williams, David R. AU - Woodruff, Peter W R AU - Wojtyniak, Bogdan AU - Xavier, Miguel AU - Zaslavsky, Alan M. TI - Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries JO - The Lancet Psychiatry VL - 10 IS - 9 SP - 668 EP - 681 PY - 2023 DA - 2023/07/30 DO - 10.1016/s2215-0366(23)00193-1 UR - https://doi.org/10.1016/s2215-0366(23)00193-1 ER -
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