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Nicolò Zuin Fantoni, Afaf Helmy El-Sagheer, Tom P Brown
Click chemistry is an immensely powerful technique for the fast and efficient covalent conjugation of molecular entities. Its broad scope has positively impacted on multiple scientific disciplines, and its implementation within the nucleic acid field has enabled researchers to generate a wide variety of tools with application in biology, biochemistry, and biotechnology. Azide-alkyne cycloadditions (AAC) are still the leading technology among click reactions due to the facile modification and incorporation of azide and alkyne groups within biological scaffolds. Application of AAC chemistry to nucleic acids allows labeling, ligation, and cyclization of oligonucleotides efficiently and cost-effectively relative to previously used chemical and enzymatic techniques. In this review, we provide a guide to inexperienced and knowledgeable researchers approaching the field of click chemistry with nucleic acids. We discuss in detail the chemistry, the available modified-nucleosides, and applications of AAC reactions in nucleic acid chemistry and provide a critical view of the advantages, limitations, and open-questions within the field.
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Fantoni, N. Z., El-Sagheer, A. H., & Brown, T. P. (2021). A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids. Chemical Reviews, 121(12), 7122–7154. https://doi.org/10.1021/acs.chemrev.0c00928
Fantoni, Nicolò Zuin, et al. "A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids." Chemical Reviews, vol. 121, no. 12, 2021, pp. 7122–7154, https://doi.org/10.1021/acs.chemrev.0c00928.
Fantoni, Nicolò Zuin, Afaf Helmy El-Sagheer, and Tom P Brown. "A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids." Chemical Reviews 121, no. 12 (2021): 7122–7154. https://doi.org/10.1021/acs.chemrev.0c00928.
Fantoni N. Z., El-Sagheer A. H., Brown T. P. A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids // Chemical Reviews. — 2021. — Vol. 121, № 12. — P. 7122–7154. — URL: https://doi.org/10.1021/acs.chemrev.0c00928
@article{fantoni2021hitchhikers,
title = {{A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids}},
author = {Nicolò Zuin Fantoni and Afaf Helmy El-Sagheer and Tom P Brown},
journal = {Chemical Reviews},
year = {2021},
volume = {121},
number = {12},
pages = {7122--7154},
doi = {10.1021/acs.chemrev.0c00928},
url = {https://doi.org/10.1021/acs.chemrev.0c00928}
}TY - JOUR AU - Fantoni, Nicolò Zuin AU - El-Sagheer, Afaf Helmy AU - Brown, Tom P TI - A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids JO - Chemical Reviews VL - 121 IS - 12 SP - 7122 EP - 7154 PY - 2021 DA - 2021/01/14 DO - 10.1021/acs.chemrev.0c00928 UR - https://doi.org/10.1021/acs.chemrev.0c00928 ER -
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