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Cheng Zhang, Kai Qi Yan, Changkui Fu, Hui Peng, Craig J. Hawker, Andrew K. Whittaker
The applications of fluorinated molecules in bioengineering and nanotechnology are expanding rapidly with the controlled introduction of fluorine being broadly studied due to the unique properties of C–F bonds. This review will focus on the design and utility of C–F containing materials in imaging, therapeutics, and environmental applications with a central theme being the importance of controlling fluorine–fluorine interactions and understanding how such interactions impact biological behavior. Low natural abundance of fluorine is shown to provide sensitivity and background advantages for imaging and detection of a variety of diseases with 19 F magnetic resonance imaging, 18 F positron emission tomography and ultrasound discussed as illustrative examples. The presence of C–F bonds can also be used to tailor membrane permeability and pharmacokinetic properties of drugs and delivery agents for enhanced cell uptake and therapeutics. A key message of this review is that while the promise of C–F containing materials is significant, a subset of highly fluorinated compounds such as per- and polyfluoroalkyl substances (PFAS), have been identified as posing a potential risk to human health. The unique properties of the C–F bond and the significant potential for fluorine–fluorine interactions in PFAS structures necessitate the development of new strategies for facile and efficient environmental removal and remediation. Recent progress in the development of fluorine-containing compounds as molecular imaging and therapeutic agents will be reviewed and their design features contrasted with environmental and health risks for PFAS systems. Finally, present challenges and future directions in the exploitation of the biological aspects of fluorinated systems will be described.
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Zhang, C., Yan, K. Q., Fu, C., Peng, H., Hawker, C. J., & Whittaker, A. K. (2021). Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation. Chemical Reviews, 122(1), 167–208. https://doi.org/10.1021/acs.chemrev.1c00632
Zhang, Cheng, et al. "Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation." Chemical Reviews, vol. 122, no. 1, 2021, pp. 167–208, https://doi.org/10.1021/acs.chemrev.1c00632.
Zhang, Cheng, Kai Qi Yan, Changkui Fu, Hui Peng, Craig J. Hawker, and Andrew K. Whittaker. "Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation." Chemical Reviews 122, no. 1 (2021): 167–208. https://doi.org/10.1021/acs.chemrev.1c00632.
Zhang C., Yan K. Q., Fu C. [и др.] Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation // Chemical Reviews. — 2021. — Vol. 122, № 1. — P. 167–208. — URL: https://doi.org/10.1021/acs.chemrev.1c00632
@article{zhang2021biological,
title = {{Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation}},
author = {Cheng Zhang and Kai Qi Yan and Changkui Fu and Hui Peng and Craig J. Hawker and Andrew K. Whittaker},
journal = {Chemical Reviews},
year = {2021},
volume = {122},
number = {1},
pages = {167--208},
doi = {10.1021/acs.chemrev.1c00632},
url = {https://doi.org/10.1021/acs.chemrev.1c00632}
}TY - JOUR AU - Zhang, Cheng AU - Yan, Kai Qi AU - Fu, Changkui AU - Peng, Hui AU - Hawker, Craig J. AU - Whittaker, Andrew K. TI - Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation JO - Chemical Reviews VL - 122 IS - 1 SP - 167 EP - 208 PY - 2021 DA - 2021/10/05 DO - 10.1021/acs.chemrev.1c00632 UR - https://doi.org/10.1021/acs.chemrev.1c00632 ER -
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