- Published
- 2022-07-17
- Venue
- Chemical Reviews, vol. 122, no. 15, pp. 12544-12747
- Cited by
- 601
- Open access
- No free copy found
- DOI
- 10.1021/acs.chemrev.1c00749
- PubMed
- 35848353
Abstract
1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic species, transfer protons, and engage in a range of other intermolecular interactions. The use of this solvent has exponentially increased in the past decade and has become a solvent of choice in some areas, such as C-H functionalization chemistry. In this review, following a brief history of HFIP in organic synthesis and an overview of its physical properties, literature examples of organic reactions using HFIP as a solvent or an additive are presented, emphasizing the effect of solvent of each reaction.
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