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Sara Kopf, Florian Bourriquen, Wu Li, Helfried Neumann, Kathrin Junge, Matthias Beller
Organic compounds labeled with hydrogen isotopes play a crucial role in numerous areas, from materials science to medicinal chemistry. Indeed, while the replacement of hydrogen by deuterium gives rise to improved absorption, distribution, metabolism, and excretion (ADME) properties in drugs and enables the preparation of internal standards for analytical mass spectrometry, the use of tritium-labeled compounds is a key technique all along drug discovery and development in the pharmaceutical industry. For these reasons, the interest in new methodologies for the isotopic enrichment of organic molecules and the extent of their applications are equally rising. In this regard, this Review intends to comprehensively discuss the new developments in this area over the last years (2017-2021). Notably, besides the fundamental hydrogen isotope exchange (HIE) reactions and the use of isotopically labeled analogues of common organic reagents, a plethora of reductive and dehalogenative deuteration techniques and other transformations with isotope incorporation are emerging and are now part of the labeling toolkit.
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Kopf, S., Bourriquen, F., Li, W., Neumann, H., Junge, K., & Beller, M. (2022). Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules. Chemical Reviews, 122(6), 6634–6718. https://doi.org/10.1021/acs.chemrev.1c00795
Kopf, Sara, et al. "Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules." Chemical Reviews, vol. 122, no. 6, 2022, pp. 6634–6718, https://doi.org/10.1021/acs.chemrev.1c00795.
Kopf, Sara, Florian Bourriquen, Wu Li, Helfried Neumann, Kathrin Junge, and Matthias Beller. "Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules." Chemical Reviews 122, no. 6 (2022): 6634–6718. https://doi.org/10.1021/acs.chemrev.1c00795.
Kopf S., Bourriquen F., Li W. [и др.] Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules // Chemical Reviews. — 2022. — Vol. 122, № 6. — P. 6634–6718. — URL: https://doi.org/10.1021/acs.chemrev.1c00795
@article{kopf2022recent,
title = {{Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules}},
author = {Sara Kopf and Florian Bourriquen and Wu Li and Helfried Neumann and Kathrin Junge and Matthias Beller},
journal = {Chemical Reviews},
year = {2022},
volume = {122},
number = {6},
pages = {6634--6718},
doi = {10.1021/acs.chemrev.1c00795},
url = {https://doi.org/10.1021/acs.chemrev.1c00795}
}TY - JOUR AU - Kopf, Sara AU - Bourriquen, Florian AU - Li, Wu AU - Neumann, Helfried AU - Junge, Kathrin AU - Beller, Matthias TI - Recent Developments for the Deuterium and Tritium Labeling of Organic Molecules JO - Chemical Reviews VL - 122 IS - 6 SP - 6634 EP - 6718 PY - 2022 DA - 2022/02/18 DO - 10.1021/acs.chemrev.1c00795 UR - https://doi.org/10.1021/acs.chemrev.1c00795 ER -
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