- Published
- 2024-02-14
- Venue
- Chemical Reviews, vol. 124, no. 4, pp. 1738-1861
- Cited by
- 413
- Open access
- No free copy found
- DOI
- 10.1021/acs.chemrev.3c00573
- PubMed
- 38354333
Abstract
The microenvironment is indispensable for functionality of various biomacromolecules, subcellular compartments, living cells, and organisms. In particular, physical properties within the biological microenvironment could exert profound effects on both the cellular physiology and pathology, with parameters including the polarity, viscosity, pH, and other relevant factors. There is a significant demand to directly visualize and quantitatively measure the fluctuation in the cellular microenvironment with spatiotemporal resolution. To satisfy this need, analytical methods based on fluorescence probes offer great opportunities due to the facile, sensitive, and dynamic detection that these molecules could enable in varying biological settings from in vitro samples to live animal models. Herein, we focus on various types of small molecule fluorescent probes for the detection and measurement of physical parameters of the microenvironment, including pH, polarity, viscosity, mechanical force, temperature, and electron potential. For each parameter, we primarily describe the chemical mechanisms underlying how physical properties are correlated with changes of various fluorescent signals. This review provides both an overview and a perspective for the development of small molecule fluorescent probes to visualize the dynamic changes in the cellular environment, to expand the knowledge for biological process, and to enrich diagnostic tools for human diseases.
Cite this paper
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- APA 7
Ma, J., Sun, R., Xia, K., Xia, Q., Liu, Y., & Zhang, X. (2024). Design and Application of Fluorescent Probes to Detect Cellular Physical Microenvironments. Chemical Reviews, 124(4), 1738–1861. https://doi.org/10.1021/acs.chemrev.3c00573
- MLA 9
Ma, Junbao, et al. "Design and Application of Fluorescent Probes to Detect Cellular Physical Microenvironments." Chemical Reviews, vol. 124, no. 4, 2024, pp. 1738–1861, https://doi.org/10.1021/acs.chemrev.3c00573.
- Chicago
Ma, Junbao, Rui Sun, Kaifu Xia, Qiuxuan Xia, Yu Liu, and Xin Zhang. "Design and Application of Fluorescent Probes to Detect Cellular Physical Microenvironments." Chemical Reviews 124, no. 4 (2024): 1738–1861. https://doi.org/10.1021/acs.chemrev.3c00573.
- GOST
Ma J., Sun R., Xia K. [и др.] Design and Application of Fluorescent Probes to Detect Cellular Physical Microenvironments // Chemical Reviews. — 2024. — Vol. 124, № 4. — P. 1738–1861. — URL: https://doi.org/10.1021/acs.chemrev.3c00573
- BibTeX
@article{ma2024design, title = {{Design and Application of Fluorescent Probes to Detect Cellular Physical Microenvironments}}, author = {Junbao Ma and Rui Sun and Kaifu Xia and Qiuxuan Xia and Yu Liu and Xin Zhang}, journal = {Chemical Reviews}, year = {2024}, volume = {124}, number = {4}, pages = {1738--1861}, doi = {10.1021/acs.chemrev.3c00573}, url = {https://doi.org/10.1021/acs.chemrev.3c00573} }- RIS
TY - JOUR AU - Ma, Junbao AU - Sun, Rui AU - Xia, Kaifu AU - Xia, Qiuxuan AU - Liu, Yu AU - Zhang, Xin TI - Design and Application of Fluorescent Probes to Detect Cellular Physical Microenvironments JO - Chemical Reviews VL - 124 IS - 4 SP - 1738 EP - 1861 PY - 2024 DA - 2024/02/14 DO - 10.1021/acs.chemrev.3c00573 UR - https://doi.org/10.1021/acs.chemrev.3c00573 ER -
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