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Maximilian A. Beach, Umeka Nayanathara, Yanting Gao, Changhe Zhang, Yijun Xiong, Yufu Wang, Georgina K. Such
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated the creation of more sophisticated drug delivery systems. Polymeric nanoparticles sit at the forefront of numerous promising drug delivery designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, and surface functionality. Furthermore, polymeric nanoparticles have the ability to navigate various biological barriers to precisely target specific sites within the body, encapsulate a diverse range of therapeutic cargo and efficiently release this cargo in response to internal and external stimuli. However, despite these remarkable advantages, the presence of polymeric nanoparticles in wider clinical application is minimal. This review will provide a comprehensive understanding of polymeric nanoparticles as drug delivery vehicles. The biological barriers affecting drug delivery will be outlined first, followed by a comprehensive description of the various nanoparticle designs and preparation methods, beginning with the polymers on which they are based. The review will meticulously explore the current performance of polymeric nanoparticles against a myriad of diseases including cancer, viral and bacterial infections, before finally evaluating the advantages and crucial challenges that will determine their wider clinical potential in the decades to come.
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Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024). Polymeric Nanoparticles for Drug Delivery. Chemical Reviews, 124(9), 5505–5616. https://doi.org/10.1021/acs.chemrev.3c00705
Beach, Maximilian A., et al. "Polymeric Nanoparticles for Drug Delivery." Chemical Reviews, vol. 124, no. 9, 2024, pp. 5505–5616, https://doi.org/10.1021/acs.chemrev.3c00705.
Beach, Maximilian A., Umeka Nayanathara, Yanting Gao, Changhe Zhang, Yijun Xiong, Yufu Wang, and Georgina K. Such. "Polymeric Nanoparticles for Drug Delivery." Chemical Reviews 124, no. 9 (2024): 5505–5616. https://doi.org/10.1021/acs.chemrev.3c00705.
Beach M. A., Nayanathara U., Gao Y. [и др.] Polymeric Nanoparticles for Drug Delivery // Chemical Reviews. — 2024. — Vol. 124, № 9. — P. 5505–5616. — URL: https://doi.org/10.1021/acs.chemrev.3c00705
@article{beach2024polymeric,
title = {{Polymeric Nanoparticles for Drug Delivery}},
author = {Maximilian A. Beach and Umeka Nayanathara and Yanting Gao and Changhe Zhang and Yijun Xiong and Yufu Wang and Georgina K. Such},
journal = {Chemical Reviews},
year = {2024},
volume = {124},
number = {9},
pages = {5505--5616},
doi = {10.1021/acs.chemrev.3c00705},
url = {https://doi.org/10.1021/acs.chemrev.3c00705}
}TY - JOUR AU - Beach, Maximilian A. AU - Nayanathara, Umeka AU - Gao, Yanting AU - Zhang, Changhe AU - Xiong, Yijun AU - Wang, Yufu AU - Such, Georgina K. TI - Polymeric Nanoparticles for Drug Delivery JO - Chemical Reviews VL - 124 IS - 9 SP - 5505 EP - 5616 PY - 2024 DA - 2024/04/16 DO - 10.1021/acs.chemrev.3c00705 UR - https://doi.org/10.1021/acs.chemrev.3c00705 ER -
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