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Harrison Lawson, S. Patrick Walton, Christina Chan
The use of metal-organic frameworks (MOFs) in biomedical applications has greatly expanded over the past decade due to the precision tunability, high surface areas, and high loading capacities of MOFs. Specifically, MOFs are being explored for a wide variety of drug delivery applications. Initially, MOFs were used for delivery of small-molecule pharmaceuticals; however, more recent work has focused on macromolecular cargos, such as proteins and nucleic acids. Here, we review the historical application of MOFs for drug delivery, with a specific focus on the available options for designing MOFs for specific drug delivery applications. These options include choices of MOF structure, synthetic method, and drug loading. Further considerations include tuning, modifications, biocompatibility, cellular targeting, and uptake. Altogether, this Review aims to guide MOF design for novel biomedical applications.
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Lawson, H., Walton, S. P., & Chan, C. (2021). Metal–Organic Frameworks for Drug Delivery: A Design Perspective. ACS Applied Materials & Interfaces, 13(6), 7004–7020. https://doi.org/10.1021/acsami.1c01089
Lawson, Harrison, et al. "Metal–Organic Frameworks for Drug Delivery: A Design Perspective." ACS Applied Materials & Interfaces, vol. 13, no. 6, 2021, pp. 7004–7020, https://doi.org/10.1021/acsami.1c01089.
Lawson, Harrison, S. Patrick Walton, and Christina Chan. "Metal–Organic Frameworks for Drug Delivery: A Design Perspective." ACS Applied Materials & Interfaces 13, no. 6 (2021): 7004–7020. https://doi.org/10.1021/acsami.1c01089.
Lawson H., Walton S. P., Chan C. Metal–Organic Frameworks for Drug Delivery: A Design Perspective // ACS Applied Materials & Interfaces. — 2021. — Vol. 13, № 6. — P. 7004–7020. — URL: https://doi.org/10.1021/acsami.1c01089
@article{lawson2021metalorganic,
title = {{Metal–Organic Frameworks for Drug Delivery: A Design Perspective}},
author = {Harrison Lawson and S. Patrick Walton and Christina Chan},
journal = {ACS Applied Materials \& Interfaces},
year = {2021},
volume = {13},
number = {6},
pages = {7004--7020},
doi = {10.1021/acsami.1c01089},
url = {https://doi.org/10.1021/acsami.1c01089}
}TY - JOUR AU - Lawson, Harrison AU - Walton, S. Patrick AU - Chan, Christina TI - Metal–Organic Frameworks for Drug Delivery: A Design Perspective JO - ACS Applied Materials & Interfaces VL - 13 IS - 6 SP - 7004 EP - 7020 PY - 2021 DA - 2021/02/07 DO - 10.1021/acsami.1c01089 UR - https://doi.org/10.1021/acsami.1c01089 ER -
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