- Published
- 2022-12-16
- Venue
- ACS Nano, vol. 17, no. 1, pp. 168-183
- Cited by
- 215
- Open access
- No free copy found
- DOI
- 10.1021/acsnano.2c05824
- PubMed
- 36524981
Abstract
The development of therapeutics for effective treatments of retinal diseases is significantly constrained by various biological barriers. We herein report a nanomedicine strategy to develop nanotherapeutics featured with not only high retinal permeability but also sustained bioactive delivery. Specifically, the nanotherapeutics are rationally designed via aminolysis of resveratrol-encapsulated polycaprolactone nanoparticles (R@PCL NPs), followed by the formation of amide linkages with carboxyl-terminated transacting activator of transcription cell penetrating peptide (T) and metformin (M). The R@PCL-T/M NP nanotherapeutics are demonstrated in vitro to possess persistent drug release profiles, good ocular biocompatibility, and potent bioactive activities for targeting prevailing risk factors associated with retinal diseases. In vivo studies indicate that single-dose intravitreal administration of the R@PCL-T/M NPs can effectively improve retinal permeability (∼15-fold increase), prevent loss of endogenous antioxidants, and suppress the growth of abnormal vessels in the retina with macular degeneration for 56 days. This high treatment efficacy can be ascribed to the enhanced retinal permeability of the nanotherapeutics in conjunction with the sustained pharmacological activity of the dual drugs (R and M) in the retinal pigment epithelial region. These findings show a great promise for the development of pharmacological nanoformulations capable of targeting the retina and thereby treating complex posterior segment diseases with improved efficacies.
Cite this paper
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- APA 7
Dung, N. D., Luo, L., Yang, C.-J., & Lai, J. (2022). Highly Retina-Permeating and Long-Acting Resveratrol/Metformin Nanotherapeutics for Enhanced Treatment of Macular Degeneration. ACS Nano, 17(1), 168–183. https://doi.org/10.1021/acsnano.2c05824
- MLA 9
Dung, Nguyen Duc, et al. "Highly Retina-Permeating and Long-Acting Resveratrol/Metformin Nanotherapeutics for Enhanced Treatment of Macular Degeneration." ACS Nano, vol. 17, no. 1, 2022, pp. 168–183, https://doi.org/10.1021/acsnano.2c05824.
- Chicago
Dung, Nguyen Duc, Li‐Jyuan Luo, Chia-Jung Yang, and Jui‐Yang Lai. "Highly Retina-Permeating and Long-Acting Resveratrol/Metformin Nanotherapeutics for Enhanced Treatment of Macular Degeneration." ACS Nano 17, no. 1 (2022): 168–183. https://doi.org/10.1021/acsnano.2c05824.
- GOST
Dung N. D., Luo L., Yang C.-J. [и др.] Highly Retina-Permeating and Long-Acting Resveratrol/Metformin Nanotherapeutics for Enhanced Treatment of Macular Degeneration // ACS Nano. — 2022. — Vol. 17, № 1. — P. 168–183. — URL: https://doi.org/10.1021/acsnano.2c05824
- BibTeX
@article{dung2022highly, title = {{Highly Retina-Permeating and Long-Acting Resveratrol/Metformin Nanotherapeutics for Enhanced Treatment of Macular Degeneration}}, author = {Nguyen Duc Dung and Li‐Jyuan Luo and Chia-Jung Yang and Jui‐Yang Lai}, journal = {ACS Nano}, year = {2022}, volume = {17}, number = {1}, pages = {168--183}, doi = {10.1021/acsnano.2c05824}, url = {https://doi.org/10.1021/acsnano.2c05824} }- RIS
TY - JOUR AU - Dung, Nguyen Duc AU - Luo, Li‐Jyuan AU - Yang, Chia-Jung AU - Lai, Jui‐Yang TI - Highly Retina-Permeating and Long-Acting Resveratrol/Metformin Nanotherapeutics for Enhanced Treatment of Macular Degeneration JO - ACS Nano VL - 17 IS - 1 SP - 168 EP - 183 PY - 2022 DA - 2022/12/16 DO - 10.1021/acsnano.2c05824 UR - https://doi.org/10.1021/acsnano.2c05824 ER -
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