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Marta Overchuk, Robert Weersink, Brian C. Wilson, Gang Zheng
Tumoricidal photodynamic (PDT) and photothermal (PTT) therapies harness light to eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen species or increasing temperature. Great strides have been made in understanding biological effects of PDT and PTT at the cellular, vascular and tumor microenvironmental levels, as well as translating both modalities in the clinic. Emerging evidence suggests that PDT and PTT may synergize due to their different mechanisms of action, and their nonoverlapping toxicity profiles make such combination potentially efficacious. Moreover, PDT/PTT combinations have gained momentum in recent years due to the development of multimodal nanoplatforms that simultaneously incorporate photodynamically- and photothermally active agents. In this review, we discuss how combining PDT and PTT can address the limitations of each modality alone and enhance treatment safety and efficacy. We provide an overview of recent literature featuring dual PDT/PTT nanoparticles and analyze the strengths and limitations of various nanoparticle design strategies. We also detail how treatment sequence and dose may affect cellular states, tumor pathophysiology and drug delivery, ultimately shaping the treatment response. Lastly, we analyze common experimental design pitfalls that complicate preclinical assessment of PDT/PTT combinations and propose rational guidelines to elucidate the mechanisms underlying PDT/PTT interactions.
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Overchuk, M., Weersink, R., Wilson, B. C., & Zheng, G. (2023). Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine. ACS Nano, 17(9), 7979–8003. https://doi.org/10.1021/acsnano.3c00891
Overchuk, Marta, et al. "Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine." ACS Nano, vol. 17, no. 9, 2023, pp. 7979–8003, https://doi.org/10.1021/acsnano.3c00891.
Overchuk, Marta, Robert Weersink, Brian C. Wilson, and Gang Zheng. "Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine." ACS Nano 17, no. 9 (2023): 7979–8003. https://doi.org/10.1021/acsnano.3c00891.
Overchuk M., Weersink R., Wilson B. C. [и др.] Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine // ACS Nano. — 2023. — Vol. 17, № 9. — P. 7979–8003. — URL: https://doi.org/10.1021/acsnano.3c00891
@article{overchuk2023photodynamic,
title = {{Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine}},
author = {Marta Overchuk and Robert Weersink and Brian C. Wilson and Gang Zheng},
journal = {ACS Nano},
year = {2023},
volume = {17},
number = {9},
pages = {7979--8003},
doi = {10.1021/acsnano.3c00891},
url = {https://doi.org/10.1021/acsnano.3c00891}
}TY - JOUR AU - Overchuk, Marta AU - Weersink, Robert AU - Wilson, Brian C. AU - Zheng, Gang TI - Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine JO - ACS Nano VL - 17 IS - 9 SP - 7979 EP - 8003 PY - 2023 DA - 2023/04/27 DO - 10.1021/acsnano.3c00891 UR - https://doi.org/10.1021/acsnano.3c00891 ER -
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