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Jun Bao, Lili Li, Yangheng Zhang, Min Wang, Fa‐Ming Chen, Shaohua Ge, Bin Chen, Fuhua Yan
The aim of this study was to identify whether periodontitis induces gut microbiota dysbiosis via invasion by salivary microbes. First, faecal and salivary samples were collected from periodontally healthy participants (PH group, n = 16) and patients with severe periodontitis (SP group, n = 21) and analysed by 16S ribosomal RNA sequencing. Significant differences were observed in both the faecal and salivary microbiota between the PH and SP groups. Notably, more saliva-sourced microbes were observed in the faecal samples of the SP group. Then, the remaining salivary microbes were transplanted into C57BL6/J mice (the C-PH group and the C-SP group), and it was found that the composition of the gut microbiota of the C-SP group was significantly different from that of the C-PH group, with Porphyromonadaceae and Fusobacterium being significantly enriched in the C-SP group. In the colon, the C-SP group showed significantly reduced crypt depth and zonula occludens-1 expression. The mRNA expression levels of pro-inflammatory cytokines, chemokines and tight junction proteins were significantly higher in the C-SP group. To further investigate whether salivary bacteria could persist in the intestine, the salivary microbiota was stained with carboxyfluorescein diacetate succinimidyl ester and transplanted into mice. We found that salivary microbes from both the PH group and the SP group could persist in the gut for at least 24 h. Thus, our data demonstrate that periodontitis may induce gut microbiota dysbiosis through the influx of salivary microbes.
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Bao, J., Li, L., Zhang, Y., Wang, M., Chen, F., Ge, S., Chen, B., & Yan, F. (2022). Periodontitis may induce gut microbiota dysbiosis via salivary microbiota. International Journal of Oral Science, 14(1), 32. https://doi.org/10.1038/s41368-022-00183-3
Bao, Jun, et al. "Periodontitis may induce gut microbiota dysbiosis via salivary microbiota." International Journal of Oral Science, vol. 14, no. 1, 2022, pp. 32, https://doi.org/10.1038/s41368-022-00183-3.
Bao, Jun, Lili Li, Yangheng Zhang, Min Wang, Fa‐Ming Chen, Shaohua Ge, Bin Chen, and Fuhua Yan. "Periodontitis may induce gut microbiota dysbiosis via salivary microbiota." International Journal of Oral Science 14, no. 1 (2022): 32. https://doi.org/10.1038/s41368-022-00183-3.
Bao J., Li L., Zhang Y. [и др.] Periodontitis may induce gut microbiota dysbiosis via salivary microbiota // International Journal of Oral Science. — 2022. — Vol. 14, № 1. — P. 32. — URL: https://doi.org/10.1038/s41368-022-00183-3
@article{bao2022periodontitis,
title = {{Periodontitis may induce gut microbiota dysbiosis via salivary microbiota}},
author = {Jun Bao and Lili Li and Yangheng Zhang and Min Wang and Fa‐Ming Chen and Shaohua Ge and Bin Chen and Fuhua Yan},
journal = {International Journal of Oral Science},
year = {2022},
volume = {14},
number = {1},
pages = {32},
doi = {10.1038/s41368-022-00183-3},
url = {https://doi.org/10.1038/s41368-022-00183-3}
}TY - JOUR AU - Bao, Jun AU - Li, Lili AU - Zhang, Yangheng AU - Wang, Min AU - Chen, Fa‐Ming AU - Ge, Shaohua AU - Chen, Bin AU - Yan, Fuhua TI - Periodontitis may induce gut microbiota dysbiosis via salivary microbiota JO - International Journal of Oral Science VL - 14 IS - 1 SP - 32 PY - 2022 DA - 2022/06/22 DO - 10.1038/s41368-022-00183-3 UR - https://doi.org/10.1038/s41368-022-00183-3 ER -
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