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Harald Juergen Hampel, John Hardy, Kaj Blennow, Christopher Chen, George L. Perry, Seung Hyun Kim, Victor L. Villemagne, Paul S. S. Aisen, Michele Vendruscolo, Takeshi Iwatsubo and 5 more
Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular mechanisms of the pathway and the spatial-temporal dynamics leading to synaptic failure, neurodegeneration, and clinical onset are still under intense investigation, the established biochemical alterations of the Aβ cycle remain the core biological hallmark of AD and are promising targets for the development of disease-modifying therapies. Here, we systematically review and update the vast state-of-the-art literature of Aβ science with evidence from basic research studies to human genetic and multi-modal biomarker investigations, which supports a crucial role of Aβ pathway dyshomeostasis in AD pathophysiological dynamics. We discuss the evidence highlighting a differentiated interaction of distinct Aβ species with other AD-related biological mechanisms, such as tau-mediated, neuroimmune and inflammatory changes, as well as a neurochemical imbalance. Through the lens of the latest development of multimodal in vivo biomarkers of AD, this cross-disciplinary review examines the compelling hypothesis- and data-driven rationale for Aβ-targeting therapeutic strategies in development for the early treatment of AD.
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Hampel, H. J., Hardy, J., Blennow, K., Chen, C., Perry, G. L., Kim, S. H., Villemagne, V. L., Aisen, P. S. S., Vendruscolo, M., Iwatsubo, T., Masters, C. L., Cho, M., Lannfelt, L., Cummings, J. L., & Vergallo, A. (2021). The Amyloid-β Pathway in Alzheimer’s Disease. Molecular Psychiatry, 26(10), 5481–5503. https://doi.org/10.1038/s41380-021-01249-0
Hampel, Harald Juergen, et al. "The Amyloid-β Pathway in Alzheimer’s Disease." Molecular Psychiatry, vol. 26, no. 10, 2021, pp. 5481–5503, https://doi.org/10.1038/s41380-021-01249-0.
Hampel, Harald Juergen, John Hardy, Kaj Blennow, Christopher Chen, George L. Perry, Seung Hyun Kim, Victor L. Villemagne, et al. "The Amyloid-β Pathway in Alzheimer’s Disease." Molecular Psychiatry 26, no. 10 (2021): 5481–5503. https://doi.org/10.1038/s41380-021-01249-0.
Hampel H. J., Hardy J., Blennow K. [и др.] The Amyloid-β Pathway in Alzheimer’s Disease // Molecular Psychiatry. — 2021. — Vol. 26, № 10. — P. 5481–5503. — URL: https://doi.org/10.1038/s41380-021-01249-0
@article{hampel2021amyloid,
title = {{The Amyloid-β Pathway in Alzheimer’s Disease}},
author = {Harald Juergen Hampel and John Hardy and Kaj Blennow and Christopher Chen and George L. Perry and Seung Hyun Kim and Victor L. Villemagne and Paul S. S. Aisen and Michele Vendruscolo and Takeshi Iwatsubo and Colin Louis Masters and Min Cho and Lars Lannfelt and Jeffrey L. Cummings and Andrea Vergallo},
journal = {Molecular Psychiatry},
year = {2021},
volume = {26},
number = {10},
pages = {5481--5503},
doi = {10.1038/s41380-021-01249-0},
url = {https://doi.org/10.1038/s41380-021-01249-0}
}TY - JOUR AU - Hampel, Harald Juergen AU - Hardy, John AU - Blennow, Kaj AU - Chen, Christopher AU - Perry, George L. AU - Kim, Seung Hyun AU - Villemagne, Victor L. AU - Aisen, Paul S. S. AU - Vendruscolo, Michele AU - Iwatsubo, Takeshi AU - Masters, Colin Louis AU - Cho, Min AU - Lannfelt, Lars AU - Cummings, Jeffrey L. AU - Vergallo, Andrea TI - The Amyloid-β Pathway in Alzheimer’s Disease JO - Molecular Psychiatry VL - 26 IS - 10 SP - 5481 EP - 5503 PY - 2021 DA - 2021/08/29 DO - 10.1038/s41380-021-01249-0 UR - https://doi.org/10.1038/s41380-021-01249-0 ER -
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