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Bei Wang, Lujin Wu, Jing Chen, Lingli Dong, Chen Chen, Wen Zheng, Jiong Hu, Ingrid Fleming, Dao Wen Wang
The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn further metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) and cytochrome P450 (CYP) enzymes to a spectrum of bioactive mediators that includes prostanoids, leukotrienes (LTs), epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid (diHETEs), eicosatetraenoic acids (ETEs), and lipoxins (LXs). Many of the latter mediators are considered to be novel preventive and therapeutic targets for cardiovascular diseases (CVD), cancers, and inflammatory diseases. This review sets out to summarize the physiological and pathophysiological importance of the AA metabolizing pathways and outline the molecular mechanisms underlying the actions of AA related to its three main metabolic pathways in CVD and cancer progression will provide valuable insight for developing new therapeutic drugs for CVD and anti-cancer agents such as inhibitors of EETs or 2J2. Thus, we herein present a synopsis of AA metabolism in human health, cardiovascular and cancer biology, and the signaling pathways involved in these processes. To explore the role of the AA metabolism and potential therapies, we also introduce the current newly clinical studies targeting AA metabolisms in the different disease conditions.
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Wang, B., Wu, L., Chen, J., Dong, L., Chen, C., Zheng, W., Hu, J., Fleming, I., & Wang, D. W. (2021). Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets. Signal Transduction and Targeted Therapy, 6(1), 94. https://doi.org/10.1038/s41392-020-00443-w
Wang, Bei, et al. "Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets." Signal Transduction and Targeted Therapy, vol. 6, no. 1, 2021, pp. 94, https://doi.org/10.1038/s41392-020-00443-w.
Wang, Bei, Lujin Wu, Jing Chen, Lingli Dong, Chen Chen, Wen Zheng, Jiong Hu, Ingrid Fleming, and Dao Wen Wang. "Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets." Signal Transduction and Targeted Therapy 6, no. 1 (2021): 94. https://doi.org/10.1038/s41392-020-00443-w.
Wang B., Wu L., Chen J. [и др.] Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets // Signal Transduction and Targeted Therapy. — 2021. — Vol. 6, № 1. — P. 94. — URL: https://doi.org/10.1038/s41392-020-00443-w
@article{wang2021metabolism,
title = {{Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets}},
author = {Bei Wang and Lujin Wu and Jing Chen and Lingli Dong and Chen Chen and Wen Zheng and Jiong Hu and Ingrid Fleming and Dao Wen Wang},
journal = {Signal Transduction and Targeted Therapy},
year = {2021},
volume = {6},
number = {1},
pages = {94},
doi = {10.1038/s41392-020-00443-w},
url = {https://doi.org/10.1038/s41392-020-00443-w}
}TY - JOUR AU - Wang, Bei AU - Wu, Lujin AU - Chen, Jing AU - Dong, Lingli AU - Chen, Chen AU - Zheng, Wen AU - Hu, Jiong AU - Fleming, Ingrid AU - Wang, Dao Wen TI - Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets JO - Signal Transduction and Targeted Therapy VL - 6 IS - 1 SP - 94 PY - 2021 DA - 2021/02/26 DO - 10.1038/s41392-020-00443-w UR - https://doi.org/10.1038/s41392-020-00443-w ER -
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