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Xiulin Jiang, Baiyang Liu, Zhi Nie, Lincan Duan, Qiuxia Xiong, Zhixian Jin, Cuiping Yang, Yongbin Chen
-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is modified by the m6A methyltransferases, or writers, such as METTL3/14/16, RBM15/15B, ZC3H3, VIRMA, CBLL1, WTAP, and KIAA1429, and, removed by the demethylases, or erasers, including FTO and ALKBH5. It is recognized by m6A-binding proteins YTHDF1/2/3, YTHDC1/2 IGF2BP1/2/3 and HNRNPA2B1, also known as "readers". Recent studies have shown that m6A RNA modification plays essential role in both physiological and pathological conditions, especially in the initiation and progression of different types of human cancers. In this review, we discuss how m6A RNA methylation influences both the physiological and pathological progressions of hematopoietic, central nervous and reproductive systems. We will mainly focus on recent progress in identifying the biological functions and the underlying molecular mechanisms of m6A RNA methylation, its regulators and downstream target genes, during cancer progression in above systems. We propose that m6A RNA methylation process offer potential targets for cancer therapy in the future.
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Jiang, X., Liu, B., Nie, Z., Duan, L., Xiong, Q., Jin, Z., Yang, C., & Chen, Y. (2021). The role of m6A modification in the biological functions and diseases. Signal Transduction and Targeted Therapy, 6(1), 74. https://doi.org/10.1038/s41392-020-00450-x
Jiang, Xiulin, et al. "The role of m6A modification in the biological functions and diseases." Signal Transduction and Targeted Therapy, vol. 6, no. 1, 2021, pp. 74, https://doi.org/10.1038/s41392-020-00450-x.
Jiang, Xiulin, Baiyang Liu, Zhi Nie, Lincan Duan, Qiuxia Xiong, Zhixian Jin, Cuiping Yang, and Yongbin Chen. "The role of m6A modification in the biological functions and diseases." Signal Transduction and Targeted Therapy 6, no. 1 (2021): 74. https://doi.org/10.1038/s41392-020-00450-x.
Jiang X., Liu B., Nie Z. [и др.] The role of m6A modification in the biological functions and diseases // Signal Transduction and Targeted Therapy. — 2021. — Vol. 6, № 1. — P. 74. — URL: https://doi.org/10.1038/s41392-020-00450-x
@article{jiang2021role,
title = {{The role of m6A modification in the biological functions and diseases}},
author = {Xiulin Jiang and Baiyang Liu and Zhi Nie and Lincan Duan and Qiuxia Xiong and Zhixian Jin and Cuiping Yang and Yongbin Chen},
journal = {Signal Transduction and Targeted Therapy},
year = {2021},
volume = {6},
number = {1},
pages = {74},
doi = {10.1038/s41392-020-00450-x},
url = {https://doi.org/10.1038/s41392-020-00450-x}
}TY - JOUR AU - Jiang, Xiulin AU - Liu, Baiyang AU - Nie, Zhi AU - Duan, Lincan AU - Xiong, Qiuxia AU - Jin, Zhixian AU - Yang, Cuiping AU - Chen, Yongbin TI - The role of m6A modification in the biological functions and diseases JO - Signal Transduction and Targeted Therapy VL - 6 IS - 1 SP - 74 PY - 2021 DA - 2021/02/20 DO - 10.1038/s41392-020-00450-x UR - https://doi.org/10.1038/s41392-020-00450-x ER -
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