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Kai Li, Houhui Shi, Benxia Zhang, Xuejin Ou, Qizhi Ma, Yue Chen, Pei Shu, Dan Li, Yongsheng Wang
Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature myeloid cells with immunosuppressive effects, which undergo massive expansion during tumor progression. These cells not only support immune escape directly but also promote tumor invasion via various non-immunological activities. Besides, this group of cells are proved to impair the efficiency of current antitumor strategies such as chemotherapy, radiotherapy, and immunotherapy. Therefore, MDSCs are considered as potential therapeutic targets for cancer therapy. Treatment strategies targeting MDSCs have shown promising outcomes in both preclinical studies and clinical trials when administrated alone, or in combination with other anticancer therapies. In this review, we shed new light on recent advances in the biological characteristics and immunosuppressive functions of MDSCs. We also hope to propose an overview of current MDSCs-targeting therapies so as to provide new ideas for cancer treatment.
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Li, K., Shi, H., Zhang, B., Ou, X., Ma, Q., Chen, Y., Shu, P., Li, D., & Wang, Y. (2021). Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer. Signal Transduction and Targeted Therapy, 6(1), 362. https://doi.org/10.1038/s41392-021-00670-9
Li, Kai, et al. "Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer." Signal Transduction and Targeted Therapy, vol. 6, no. 1, 2021, pp. 362, https://doi.org/10.1038/s41392-021-00670-9.
Li, Kai, Houhui Shi, Benxia Zhang, Xuejin Ou, Qizhi Ma, Yue Chen, Pei Shu, Dan Li, and Yongsheng Wang. "Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer." Signal Transduction and Targeted Therapy 6, no. 1 (2021): 362. https://doi.org/10.1038/s41392-021-00670-9.
Li K., Shi H., Zhang B. [и др.] Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer // Signal Transduction and Targeted Therapy. — 2021. — Vol. 6, № 1. — P. 362. — URL: https://doi.org/10.1038/s41392-021-00670-9
@article{li2021myeloidderived,
title = {{Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer}},
author = {Kai Li and Houhui Shi and Benxia Zhang and Xuejin Ou and Qizhi Ma and Yue Chen and Pei Shu and Dan Li and Yongsheng Wang},
journal = {Signal Transduction and Targeted Therapy},
year = {2021},
volume = {6},
number = {1},
pages = {362},
doi = {10.1038/s41392-021-00670-9},
url = {https://doi.org/10.1038/s41392-021-00670-9}
}TY - JOUR AU - Li, Kai AU - Shi, Houhui AU - Zhang, Benxia AU - Ou, Xuejin AU - Ma, Qizhi AU - Chen, Yue AU - Shu, Pei AU - Li, Dan AU - Wang, Yongsheng TI - Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer JO - Signal Transduction and Targeted Therapy VL - 6 IS - 1 SP - 362 PY - 2021 DA - 2021/10/07 DO - 10.1038/s41392-021-00670-9 UR - https://doi.org/10.1038/s41392-021-00670-9 ER -
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