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Jiaqi Liu, Qing Xiao, Jiani Xiao, Chenxi Niu, Yuanyuan Li, Xiaojun Zhang, Zhengwei Zhou, Guang Shu, Gang Yin
The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.
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Liu, J., Xiao, Q., Xiao, J., Niu, C., Li, Y., Zhang, X., Zhou, Z., Shu, G., & Yin, G. (2022). Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities. Signal Transduction and Targeted Therapy, 7(1), 3. https://doi.org/10.1038/s41392-021-00762-6
Liu, Jiaqi, et al. "Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities." Signal Transduction and Targeted Therapy, vol. 7, no. 1, 2022, pp. 3, https://doi.org/10.1038/s41392-021-00762-6.
Liu, Jiaqi, Qing Xiao, Jiani Xiao, Chenxi Niu, Yuanyuan Li, Xiaojun Zhang, Zhengwei Zhou, Guang Shu, and Gang Yin. "Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities." Signal Transduction and Targeted Therapy 7, no. 1 (2022): 3. https://doi.org/10.1038/s41392-021-00762-6.
Liu J., Xiao Q., Xiao J. [и др.] Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities // Signal Transduction and Targeted Therapy. — 2022. — Vol. 7, № 1. — P. 3. — URL: https://doi.org/10.1038/s41392-021-00762-6
@article{liu2022wntcatenin,
title = {{Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities}},
author = {Jiaqi Liu and Qing Xiao and Jiani Xiao and Chenxi Niu and Yuanyuan Li and Xiaojun Zhang and Zhengwei Zhou and Guang Shu and Gang Yin},
journal = {Signal Transduction and Targeted Therapy},
year = {2022},
volume = {7},
number = {1},
pages = {3},
doi = {10.1038/s41392-021-00762-6},
url = {https://doi.org/10.1038/s41392-021-00762-6}
}TY - JOUR AU - Liu, Jiaqi AU - Xiao, Qing AU - Xiao, Jiani AU - Niu, Chenxi AU - Li, Yuanyuan AU - Zhang, Xiaojun AU - Zhou, Zhengwei AU - Shu, Guang AU - Yin, Gang TI - Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities JO - Signal Transduction and Targeted Therapy VL - 7 IS - 1 SP - 3 PY - 2022 DA - 2022/01/03 DO - 10.1038/s41392-021-00762-6 UR - https://doi.org/10.1038/s41392-021-00762-6 ER -
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