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Xiaoyi Hu, Jing Li, Maorong Fu, Xia Zhao, Wei Wang
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pathway. Moreover, we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases.
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Hu, X., Li, J., Fu, M., Zhao, X., & Wang, W. (2021). The JAK/STAT signaling pathway: from bench to clinic. Signal Transduction and Targeted Therapy, 6(1), 402. https://doi.org/10.1038/s41392-021-00791-1
Hu, Xiaoyi, et al. "The JAK/STAT signaling pathway: from bench to clinic." Signal Transduction and Targeted Therapy, vol. 6, no. 1, 2021, pp. 402, https://doi.org/10.1038/s41392-021-00791-1.
Hu, Xiaoyi, Jing Li, Maorong Fu, Xia Zhao, and Wei Wang. "The JAK/STAT signaling pathway: from bench to clinic." Signal Transduction and Targeted Therapy 6, no. 1 (2021): 402. https://doi.org/10.1038/s41392-021-00791-1.
Hu X., Li J., Fu M. [и др.] The JAK/STAT signaling pathway: from bench to clinic // Signal Transduction and Targeted Therapy. — 2021. — Vol. 6, № 1. — P. 402. — URL: https://doi.org/10.1038/s41392-021-00791-1
@article{hu2021jakstat,
title = {{The JAK/STAT signaling pathway: from bench to clinic}},
author = {Xiaoyi Hu and Jing Li and Maorong Fu and Xia Zhao and Wei Wang},
journal = {Signal Transduction and Targeted Therapy},
year = {2021},
volume = {6},
number = {1},
pages = {402},
doi = {10.1038/s41392-021-00791-1},
url = {https://doi.org/10.1038/s41392-021-00791-1}
}TY - JOUR AU - Hu, Xiaoyi AU - Li, Jing AU - Fu, Maorong AU - Zhao, Xia AU - Wang, Wei TI - The JAK/STAT signaling pathway: from bench to clinic JO - Signal Transduction and Targeted Therapy VL - 6 IS - 1 SP - 402 PY - 2021 DA - 2021/11/26 DO - 10.1038/s41392-021-00791-1 UR - https://doi.org/10.1038/s41392-021-00791-1 ER -
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