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Yan He, Miao Sun, Guo Geng Zhang, Jing Yang, Kui Sheng Chen, Wen Wen Xu, Bin Li
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers, contributing to the occurrence and progression of tumors. Examining the upstream and downstream nodes of this pathway could allow full elucidation of its function. Based on accumulating evidence, strategies targeting major components of the pathway might provide new insights for cancer drug discovery. Researchers have explored the use of some inhibitors targeting this pathway to block survival pathways. However, because oncogenic PI3K pathway activation occurs through various mechanisms, the clinical efficacies of these inhibitors are limited. Moreover, pathway activation is accompanied by the development of therapeutic resistance. Therefore, strategies involving pathway inhibitors and other cancer treatments in combination might solve the therapeutic dilemma. In this review, we discuss the roles of the PI3K/Akt pathway in various cancer phenotypes, review the current statuses of different PI3K/Akt inhibitors, and introduce combination therapies consisting of signaling inhibitors and conventional cancer therapies. The information presented herein suggests that cascading inhibitors of the PI3K/Akt signaling pathway, either alone or in combination with other therapies, are the most effective treatment strategy for cancer.
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He, Y., Sun, M., Zhang, G. G., Yang, J., Chen, K. S., Xu, W. W., & Li, B. (2021). Targeting PI3K/Akt signal transduction for cancer therapy. Signal Transduction and Targeted Therapy, 6(1), 425. https://doi.org/10.1038/s41392-021-00828-5
He, Yan, et al. "Targeting PI3K/Akt signal transduction for cancer therapy." Signal Transduction and Targeted Therapy, vol. 6, no. 1, 2021, pp. 425, https://doi.org/10.1038/s41392-021-00828-5.
He, Yan, Miao Sun, Guo Geng Zhang, Jing Yang, Kui Sheng Chen, Wen Wen Xu, and Bin Li. "Targeting PI3K/Akt signal transduction for cancer therapy." Signal Transduction and Targeted Therapy 6, no. 1 (2021): 425. https://doi.org/10.1038/s41392-021-00828-5.
He Y., Sun M., Zhang G. G. [и др.] Targeting PI3K/Akt signal transduction for cancer therapy // Signal Transduction and Targeted Therapy. — 2021. — Vol. 6, № 1. — P. 425. — URL: https://doi.org/10.1038/s41392-021-00828-5
@article{he2021targeting,
title = {{Targeting PI3K/Akt signal transduction for cancer therapy}},
author = {Yan He and Miao Sun and Guo Geng Zhang and Jing Yang and Kui Sheng Chen and Wen Wen Xu and Bin Li},
journal = {Signal Transduction and Targeted Therapy},
year = {2021},
volume = {6},
number = {1},
pages = {425},
doi = {10.1038/s41392-021-00828-5},
url = {https://doi.org/10.1038/s41392-021-00828-5}
}TY - JOUR AU - He, Yan AU - Sun, Miao AU - Zhang, Guo Geng AU - Yang, Jing AU - Chen, Kui Sheng AU - Xu, Wen Wen AU - Li, Bin TI - Targeting PI3K/Akt signal transduction for cancer therapy JO - Signal Transduction and Targeted Therapy VL - 6 IS - 1 SP - 425 PY - 2021 DA - 2021/12/16 DO - 10.1038/s41392-021-00828-5 UR - https://doi.org/10.1038/s41392-021-00828-5 ER -
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