One connector, four scholarly indexes, real DOIs and legal free PDFs. Works in Claude and ChatGPT.
Paste it into Claude or ChatGPT as a custom connector. 3-day free trial.
Huấn Cao, Lixia Duan, Yan Zhang, Jun Cao, Kun Zhang
Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) and influence cell signaling cascades and fate. In the past few decades, a plethora of pioneering studies have been implemented to explore the cell-hydrogel matrix interactions and figure out the underlying mechanisms, paving the way to the lab-to-clinic translation of hydrogel-based therapies. In this review, we first introduced the physicochemical properties of hydrogels and their fabrication approaches concisely. Subsequently, the comprehensive description and deep discussion were elucidated, wherein the influences of different hydrogels properties on cell behaviors and cellular signaling events were highlighted. These behaviors or events included integrin clustering, focal adhesion (FA) complex accumulation and activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling and activation (e.g., Yes-associated protein (YAP), catenin, etc.), cellular compartment reorganization, gene expression, and further cell biology modulation (e.g., spreading, migration, proliferation, lineage commitment, etc.). Based on them, current in vitro and in vivo hydrogel applications that mainly covered diseases models, various cell delivery protocols for tissue regeneration and disease therapy, smart drug carrier, bioimaging, biosensor, and conductive wearable/implantable biodevices, etc. were further summarized and discussed. More significantly, the clinical translation potential and trials of hydrogels were presented, accompanied with which the remaining challenges and future perspectives in this field were emphasized. Collectively, the comprehensive and deep insights in this review will shed light on the design principles of new biomedical hydrogels to understand and modulate cellular processes, which are available for providing significant indications for future hydrogel design and serving for a broad range of biomedical applications.
Formatted from the source metadata, not typed by hand. For a whole reference list, use the citation generator or ask your assistant through Find Research.
Cao, H., Duan, L., Zhang, Y., Cao, J., & Zhang, K. (2021). Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity. Signal Transduction and Targeted Therapy, 6(1), 426. https://doi.org/10.1038/s41392-021-00830-x
Cao, Huấn, et al. "Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity." Signal Transduction and Targeted Therapy, vol. 6, no. 1, 2021, pp. 426, https://doi.org/10.1038/s41392-021-00830-x.
Cao, Huấn, Lixia Duan, Yan Zhang, Jun Cao, and Kun Zhang. "Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity." Signal Transduction and Targeted Therapy 6, no. 1 (2021): 426. https://doi.org/10.1038/s41392-021-00830-x.
Cao H., Duan L., Zhang Y. [и др.] Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity // Signal Transduction and Targeted Therapy. — 2021. — Vol. 6, № 1. — P. 426. — URL: https://doi.org/10.1038/s41392-021-00830-x
@article{cao2021current,
title = {{Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity}},
author = {Huấn Cao and Lixia Duan and Yan Zhang and Jun Cao and Kun Zhang},
journal = {Signal Transduction and Targeted Therapy},
year = {2021},
volume = {6},
number = {1},
pages = {426},
doi = {10.1038/s41392-021-00830-x},
url = {https://doi.org/10.1038/s41392-021-00830-x}
}TY - JOUR AU - Cao, Huấn AU - Duan, Lixia AU - Zhang, Yan AU - Cao, Jun AU - Zhang, Kun TI - Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity JO - Signal Transduction and Targeted Therapy VL - 6 IS - 1 SP - 426 PY - 2021 DA - 2021/12/16 DO - 10.1038/s41392-021-00830-x UR - https://doi.org/10.1038/s41392-021-00830-x ER -
Add Find Research to Claude or ChatGPT and ask in plain language. The assistant reads this record, finds the papers around it and cites only what it actually found:
Setup takes about a minute: add the connector, then start the free trial.
Record from OpenAlex; open-access location from Unpaywall and the indexes. Find Research links only to legal copies.