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Francesca Fagiani, Daniele Di Marino, Alice Romagnoli, Cristina Travelli, Davide Voltan, Lorenzo Di Cesare Mannelli, Marco Racchi, Stefano M. Govoni, Cristina Lanni
The term "circadian rhythms" describes endogenous oscillations with ca. 24-h period associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the existence of an intrinsic circadian clock that temporally orchestrates physiological processes to adapt the internal environment with the external cues. At the molecular level, the circadian clock consists of multiple sets of transcription factors resulting in autoregulatory transcription-translation feedback loops. Notably, in addition to their primary role as generator of circadian rhythm, the biological clock plays a key role in controlling physiological functions of almost all tissues and organs. It regulates several intracellular signaling pathways, ranging from cell proliferation, DNA damage repair and response, angiogenesis, metabolic and redox homeostasis, to inflammatory and immune response. In this review, we summarize findings showing the crosstalk between the circadian molecular clock and some key intracellular pathways, describing a scenario wherein their reciprocal regulation impinges upon several aspects of mammalian physiology. Moreover, based on evidence indicating that circadian rhythms can be challenged by environmental factors, social behaviors, as well as pre-existing pathological conditions, we discuss implications of circadian misalignment in human pathologies, such as cancer and inflammatory diseases. Accordingly, disruption of circadian rhythm has been reported to affect several physiological processes that are relevant to human diseases. Expanding our understanding of this field represents an intriguing and transversal medicine challenge in order to establish a circadian precision medicine.
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Fagiani, F., Marino, D. D., Romagnoli, A., Travelli, C., Voltan, D., Mannelli, L. D. C., Racchi, M., Govoni, S. M., & Lanni, C. (2022). Molecular regulations of circadian rhythm and implications for physiology and diseases. Signal Transduction and Targeted Therapy, 7(1), 41. https://doi.org/10.1038/s41392-022-00899-y
Fagiani, Francesca, et al. "Molecular regulations of circadian rhythm and implications for physiology and diseases." Signal Transduction and Targeted Therapy, vol. 7, no. 1, 2022, pp. 41, https://doi.org/10.1038/s41392-022-00899-y.
Fagiani, Francesca, Daniele Di Marino, Alice Romagnoli, Cristina Travelli, Davide Voltan, Lorenzo Di Cesare Mannelli, Marco Racchi, Stefano M. Govoni, and Cristina Lanni. "Molecular regulations of circadian rhythm and implications for physiology and diseases." Signal Transduction and Targeted Therapy 7, no. 1 (2022): 41. https://doi.org/10.1038/s41392-022-00899-y.
Fagiani F., Marino D. D., Romagnoli A. [и др.] Molecular regulations of circadian rhythm and implications for physiology and diseases // Signal Transduction and Targeted Therapy. — 2022. — Vol. 7, № 1. — P. 41. — URL: https://doi.org/10.1038/s41392-022-00899-y
@article{fagiani2022molecular,
title = {{Molecular regulations of circadian rhythm and implications for physiology and diseases}},
author = {Francesca Fagiani and Daniele Di Marino and Alice Romagnoli and Cristina Travelli and Davide Voltan and Lorenzo Di Cesare Mannelli and Marco Racchi and Stefano M. Govoni and Cristina Lanni},
journal = {Signal Transduction and Targeted Therapy},
year = {2022},
volume = {7},
number = {1},
pages = {41},
doi = {10.1038/s41392-022-00899-y},
url = {https://doi.org/10.1038/s41392-022-00899-y}
}TY - JOUR AU - Fagiani, Francesca AU - Marino, Daniele Di AU - Romagnoli, Alice AU - Travelli, Cristina AU - Voltan, Davide AU - Mannelli, Lorenzo Di Cesare AU - Racchi, Marco AU - Govoni, Stefano M. AU - Lanni, Cristina TI - Molecular regulations of circadian rhythm and implications for physiology and diseases JO - Signal Transduction and Targeted Therapy VL - 7 IS - 1 SP - 41 PY - 2022 DA - 2022/02/08 DO - 10.1038/s41392-022-00899-y UR - https://doi.org/10.1038/s41392-022-00899-y ER -
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