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Xue Wen, Bohan Zhang, Beiyi Wu, Haitao Xiao, Zehua Li, Ruoyu Li, Xuewen Xu, Tao Li
Obesity is a complex, chronic disease and global public health challenge. Characterized by excessive fat accumulation in the body, obesity sharply increases the risk of several diseases, such as type 2 diabetes, cardiovascular disease, and nonalcoholic fatty liver disease, and is linked to lower life expectancy. Although lifestyle intervention (diet and exercise) has remarkable effects on weight management, achieving long-term success at weight loss is extremely challenging, and the prevalence of obesity continues to rise worldwide. Over the past decades, the pathophysiology of obesity has been extensively investigated, and an increasing number of signal transduction pathways have been implicated in obesity, making it possible to fight obesity in a more effective and precise way. In this review, we summarize recent advances in the pathogenesis of obesity from both experimental and clinical studies, focusing on signaling pathways and their roles in the regulation of food intake, glucose homeostasis, adipogenesis, thermogenesis, and chronic inflammation. We also discuss the current anti-obesity drugs, as well as weight loss compounds in clinical trials, that target these signals. The evolving knowledge of signaling transduction may shed light on the future direction of obesity research, as we move into a new era of precision medicine.
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Wen, X., Zhang, B., Wu, B., Xiao, H., Li, Z., Li, R., Xu, X., & Li, T. (2022). Signaling pathways in obesity: mechanisms and therapeutic interventions. Signal Transduction and Targeted Therapy, 7(1), 298. https://doi.org/10.1038/s41392-022-01149-x
Wen, Xue, et al. "Signaling pathways in obesity: mechanisms and therapeutic interventions." Signal Transduction and Targeted Therapy, vol. 7, no. 1, 2022, pp. 298, https://doi.org/10.1038/s41392-022-01149-x.
Wen, Xue, Bohan Zhang, Beiyi Wu, Haitao Xiao, Zehua Li, Ruoyu Li, Xuewen Xu, and Tao Li. "Signaling pathways in obesity: mechanisms and therapeutic interventions." Signal Transduction and Targeted Therapy 7, no. 1 (2022): 298. https://doi.org/10.1038/s41392-022-01149-x.
Wen X., Zhang B., Wu B. [и др.] Signaling pathways in obesity: mechanisms and therapeutic interventions // Signal Transduction and Targeted Therapy. — 2022. — Vol. 7, № 1. — P. 298. — URL: https://doi.org/10.1038/s41392-022-01149-x
@article{wen2022signaling,
title = {{Signaling pathways in obesity: mechanisms and therapeutic interventions}},
author = {Xue Wen and Bohan Zhang and Beiyi Wu and Haitao Xiao and Zehua Li and Ruoyu Li and Xuewen Xu and Tao Li},
journal = {Signal Transduction and Targeted Therapy},
year = {2022},
volume = {7},
number = {1},
pages = {298},
doi = {10.1038/s41392-022-01149-x},
url = {https://doi.org/10.1038/s41392-022-01149-x}
}TY - JOUR AU - Wen, Xue AU - Zhang, Bohan AU - Wu, Beiyi AU - Xiao, Haitao AU - Li, Zehua AU - Li, Ruoyu AU - Xu, Xuewen AU - Li, Tao TI - Signaling pathways in obesity: mechanisms and therapeutic interventions JO - Signal Transduction and Targeted Therapy VL - 7 IS - 1 SP - 298 PY - 2022 DA - 2022/08/28 DO - 10.1038/s41392-022-01149-x UR - https://doi.org/10.1038/s41392-022-01149-x ER -
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