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Weifeng Zhang, Dan Xiao, Qinwen Mao, Haibin Xia
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that inflammation is not only a result of neurodegeneration but also a crucial player in this process. Protein aggregates which are very common pathological phenomenon in neurodegeneration can induce neuroinflammation which further aggravates protein aggregation and neurodegeneration. Actually, inflammation even happens earlier than protein aggregation. Neuroinflammation induced by genetic variations in CNS cells or by peripheral immune cells may induce protein deposition in some susceptible population. Numerous signaling pathways and a range of CNS cells have been suggested to be involved in the pathogenesis of neurodegeneration, although they are still far from being completely understood. Due to the limited success of traditional treatment methods, blocking or enhancing inflammatory signaling pathways involved in neurodegeneration are considered to be promising strategies for the therapy of neurodegenerative diseases, and many of them have got exciting results in animal models or clinical trials. Some of them, although very few, have been approved by FDA for clinical usage. Here we comprehensively review the factors affecting neuroinflammation and the major inflammatory signaling pathways involved in the pathogenicity of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis. We also summarize the current strategies, both in animal models and in the clinic, for the treatment of neurodegenerative diseases.
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Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023). Role of neuroinflammation in neurodegeneration development. Signal Transduction and Targeted Therapy, 8(1), 267. https://doi.org/10.1038/s41392-023-01486-5
Zhang, Weifeng, et al. "Role of neuroinflammation in neurodegeneration development." Signal Transduction and Targeted Therapy, vol. 8, no. 1, 2023, pp. 267, https://doi.org/10.1038/s41392-023-01486-5.
Zhang, Weifeng, Dan Xiao, Qinwen Mao, and Haibin Xia. "Role of neuroinflammation in neurodegeneration development." Signal Transduction and Targeted Therapy 8, no. 1 (2023): 267. https://doi.org/10.1038/s41392-023-01486-5.
Zhang W., Xiao D., Mao Q. [и др.] Role of neuroinflammation in neurodegeneration development // Signal Transduction and Targeted Therapy. — 2023. — Vol. 8, № 1. — P. 267. — URL: https://doi.org/10.1038/s41392-023-01486-5
@article{zhang2023role,
title = {{Role of neuroinflammation in neurodegeneration development}},
author = {Weifeng Zhang and Dan Xiao and Qinwen Mao and Haibin Xia},
journal = {Signal Transduction and Targeted Therapy},
year = {2023},
volume = {8},
number = {1},
pages = {267},
doi = {10.1038/s41392-023-01486-5},
url = {https://doi.org/10.1038/s41392-023-01486-5}
}TY - JOUR AU - Zhang, Weifeng AU - Xiao, Dan AU - Mao, Qinwen AU - Xia, Haibin TI - Role of neuroinflammation in neurodegeneration development JO - Signal Transduction and Targeted Therapy VL - 8 IS - 1 SP - 267 PY - 2023 DA - 2023/07/11 DO - 10.1038/s41392-023-01486-5 UR - https://doi.org/10.1038/s41392-023-01486-5 ER -
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