One connector, four scholarly indexes, real DOIs and legal free PDFs. Works in Claude and ChatGPT.
Paste it into Claude or ChatGPT as a custom connector. 3-day free trial.
Chao Gao, Jingwen Jiang, Yuyan Tan, Shengdi Chen
Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity. Some identified microglia in specific states correlate with pathological hallmarks and are associated with specific functions. Microglia both exert protective function by phagocytosing and clearing pathological protein aggregates and play detrimental roles due to excessive uptake of protein aggregates, which would lead to microglial phagocytic ability impairment, neuroinflammation, and eventually neurodegeneration. In addition, peripheral immune cells infiltration shapes microglia into a pro-inflammatory phenotype and accelerates disease progression. Microglia also act as a mobile vehicle to propagate protein aggregates. Extracellular vesicles released from microglia and autophagy impairment in microglia all contribute to pathological progression and neurodegeneration. Thus, enhancing microglial phagocytosis, reducing microglial-mediated neuroinflammation, inhibiting microglial exosome synthesis and secretion, and promoting microglial conversion into a protective phenotype are considered to be promising strategies for the therapy of neurodegenerative diseases. Here we comprehensively review the biology of microglia and the roles of microglia in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple system atrophy, amyotrophic lateral sclerosis, frontotemporal dementia, progressive supranuclear palsy, corticobasal degeneration, dementia with Lewy bodies and Huntington's disease. We also summarize the possible microglia-targeted interventions and treatments against neurodegenerative diseases with preclinical and clinical evidence in cell experiments, animal studies, and clinical trials.
Formatted from the source metadata, not typed by hand. For a whole reference list, use the citation generator or ask your assistant through Find Research.
Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023). Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal Transduction and Targeted Therapy, 8(1), 359. https://doi.org/10.1038/s41392-023-01588-0
Gao, Chao, et al. "Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets." Signal Transduction and Targeted Therapy, vol. 8, no. 1, 2023, pp. 359, https://doi.org/10.1038/s41392-023-01588-0.
Gao, Chao, Jingwen Jiang, Yuyan Tan, and Shengdi Chen. "Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets." Signal Transduction and Targeted Therapy 8, no. 1 (2023): 359. https://doi.org/10.1038/s41392-023-01588-0.
Gao C., Jiang J., Tan Y. [и др.] Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets // Signal Transduction and Targeted Therapy. — 2023. — Vol. 8, № 1. — P. 359. — URL: https://doi.org/10.1038/s41392-023-01588-0
@article{gao2023microglia,
title = {{Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets}},
author = {Chao Gao and Jingwen Jiang and Yuyan Tan and Shengdi Chen},
journal = {Signal Transduction and Targeted Therapy},
year = {2023},
volume = {8},
number = {1},
pages = {359},
doi = {10.1038/s41392-023-01588-0},
url = {https://doi.org/10.1038/s41392-023-01588-0}
}TY - JOUR AU - Gao, Chao AU - Jiang, Jingwen AU - Tan, Yuyan AU - Chen, Shengdi TI - Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets JO - Signal Transduction and Targeted Therapy VL - 8 IS - 1 SP - 359 PY - 2023 DA - 2023/09/21 DO - 10.1038/s41392-023-01588-0 UR - https://doi.org/10.1038/s41392-023-01588-0 ER -
Add Find Research to Claude or ChatGPT and ask in plain language. The assistant reads this record, finds the papers around it and cites only what it actually found:
Setup takes about a minute: add the connector, then start the free trial.
Record from OpenAlex; open-access location from Unpaywall and the indexes. Find Research links only to legal copies.