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Ting Fan, Mingna Zhang, Jingxian Yang, Zhounan Zhu, Wanlu Cao, Chunyan Dong
With the development and regulatory approval of immune checkpoint inhibitors and adoptive cell therapies, cancer immunotherapy has undergone a profound transformation over the past decades. Recently, therapeutic cancer vaccines have shown promise by eliciting de novo T cell responses targeting tumor antigens, including tumor-associated antigens and tumor-specific antigens. The objective was to amplify and diversify the intrinsic repertoire of tumor-specific T cells. However, the complete realization of these capabilities remains an ongoing pursuit. Therefore, we provide an overview of the current landscape of cancer vaccines in this review. The range of antigen selection, antigen delivery systems development the strategic nuances underlying effective antigen presentation have pioneered cancer vaccine design. Furthermore, this review addresses the current status of clinical trials and discusses their strategies, focusing on tumor-specific immunogenicity and anti-tumor efficacy assessment. However, current clinical attempts toward developing cancer vaccines have not yielded breakthrough clinical outcomes due to significant challenges, including tumor immune microenvironment suppression, optimal candidate identification, immune response evaluation, and vaccine manufacturing acceleration. Therefore, the field is poised to overcome hurdles and improve patient outcomes in the future by acknowledging these clinical complexities and persistently striving to surmount inherent constraints.
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Fan, T., Zhang, M., Yang, J., Zhu, Z., Cao, W., & Dong, C. (2023). Therapeutic cancer vaccines: advancements, challenges and prospects. Signal Transduction and Targeted Therapy, 8(1), 450. https://doi.org/10.1038/s41392-023-01674-3
Fan, Ting, et al. "Therapeutic cancer vaccines: advancements, challenges and prospects." Signal Transduction and Targeted Therapy, vol. 8, no. 1, 2023, pp. 450, https://doi.org/10.1038/s41392-023-01674-3.
Fan, Ting, Mingna Zhang, Jingxian Yang, Zhounan Zhu, Wanlu Cao, and Chunyan Dong. "Therapeutic cancer vaccines: advancements, challenges and prospects." Signal Transduction and Targeted Therapy 8, no. 1 (2023): 450. https://doi.org/10.1038/s41392-023-01674-3.
Fan T., Zhang M., Yang J. [и др.] Therapeutic cancer vaccines: advancements, challenges and prospects // Signal Transduction and Targeted Therapy. — 2023. — Vol. 8, № 1. — P. 450. — URL: https://doi.org/10.1038/s41392-023-01674-3
@article{fan2023therapeutic,
title = {{Therapeutic cancer vaccines: advancements, challenges and prospects}},
author = {Ting Fan and Mingna Zhang and Jingxian Yang and Zhounan Zhu and Wanlu Cao and Chunyan Dong},
journal = {Signal Transduction and Targeted Therapy},
year = {2023},
volume = {8},
number = {1},
pages = {450},
doi = {10.1038/s41392-023-01674-3},
url = {https://doi.org/10.1038/s41392-023-01674-3}
}TY - JOUR AU - Fan, Ting AU - Zhang, Mingna AU - Yang, Jingxian AU - Zhu, Zhounan AU - Cao, Wanlu AU - Dong, Chunyan TI - Therapeutic cancer vaccines: advancements, challenges and prospects JO - Signal Transduction and Targeted Therapy VL - 8 IS - 1 SP - 450 PY - 2023 DA - 2023/12/12 DO - 10.1038/s41392-023-01674-3 UR - https://doi.org/10.1038/s41392-023-01674-3 ER -
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