One connector, four scholarly indexes, real DOIs and legal free PDFs. Works in Claude and ChatGPT.
Paste it into Claude or ChatGPT as a custom connector. 3-day free trial.
Robert C. Sterner, Rosalie M. Sterner, Rosalie M. Sterner, Rosalie M. Sterner
Chimeric antigen receptor (CAR)-T cell therapy is a revolutionary new pillar in cancer treatment. Although treatment with CAR-T cells has produced remarkable clinical responses with certain subsets of B cell leukemia or lymphoma, many challenges limit the therapeutic efficacy of CAR-T cells in solid tumors and hematological malignancies. Barriers to effective CAR-T cell therapy include severe life-threatening toxicities, modest anti-tumor activity, antigen escape, restricted trafficking, and limited tumor infiltration. In addition, the host and tumor microenvironment interactions with CAR-T cells critically alter CAR-T cell function. Furthermore, a complex workforce is required to develop and implement these treatments. In order to overcome these significant challenges, innovative strategies and approaches to engineer more powerful CAR-T cells with improved anti-tumor activity and decreased toxicity are necessary. In this review, we discuss recent innovations in CAR-T cell engineering to improve clinical efficacy in both hematological malignancy and solid tumors and strategies to overcome limitations of CAR-T cell therapy in both hematological malignancy and solid tumors.
Formatted from the source metadata, not typed by hand. For a whole reference list, use the citation generator or ask your assistant through Find Research.
Sterner, R. C., Sterner, R. M., Sterner, R. M., & Sterner, R. M. (2021). CAR-T cell therapy: current limitations and potential strategies. Blood Cancer Journal, 11(4), 69. https://doi.org/10.1038/s41408-021-00459-7
Sterner, Robert C., et al. "CAR-T cell therapy: current limitations and potential strategies." Blood Cancer Journal, vol. 11, no. 4, 2021, pp. 69, https://doi.org/10.1038/s41408-021-00459-7.
Sterner, Robert C., Rosalie M. Sterner, Rosalie M. Sterner, and Rosalie M. Sterner. "CAR-T cell therapy: current limitations and potential strategies." Blood Cancer Journal 11, no. 4 (2021): 69. https://doi.org/10.1038/s41408-021-00459-7.
Sterner R. C., Sterner R. M., Sterner R. M. [и др.] CAR-T cell therapy: current limitations and potential strategies // Blood Cancer Journal. — 2021. — Vol. 11, № 4. — P. 69. — URL: https://doi.org/10.1038/s41408-021-00459-7
@article{sterner2021cart,
title = {{CAR-T cell therapy: current limitations and potential strategies}},
author = {Robert C. Sterner and Rosalie M. Sterner and Rosalie M. Sterner and Rosalie M. Sterner},
journal = {Blood Cancer Journal},
year = {2021},
volume = {11},
number = {4},
pages = {69},
doi = {10.1038/s41408-021-00459-7},
url = {https://doi.org/10.1038/s41408-021-00459-7}
}TY - JOUR AU - Sterner, Robert C. AU - Sterner, Rosalie M. AU - Sterner, Rosalie M. AU - Sterner, Rosalie M. TI - CAR-T cell therapy: current limitations and potential strategies JO - Blood Cancer Journal VL - 11 IS - 4 SP - 69 PY - 2021 DA - 2021/04/06 DO - 10.1038/s41408-021-00459-7 UR - https://doi.org/10.1038/s41408-021-00459-7 ER -
Add Find Research to Claude or ChatGPT and ask in plain language. The assistant reads this record, finds the papers around it and cites only what it actually found:
Setup takes about a minute: add the connector, then start the free trial.
Record from OpenAlex; open-access location from Unpaywall and the indexes. Find Research links only to legal copies.