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Ane Charlotte Christensen, Kristian Kinden Lensjø, Mikkel Elle Lepperød, Svenn-Arne Dragly, Halvard Sutterud, Jan Sigurd Blackstad, Marianne Fyhn, Torkel Hafting
Grid cells are part of a widespread network which supports navigation and spatial memory. Stable grid patterns appear late in development, in concert with extracellular matrix aggregates termed perineuronal nets (PNNs) that condense around inhibitory neurons. It has been suggested that PNNs stabilize synaptic connections and long-term memories, but their role in the grid cell network remains elusive. We show that removal of PNNs leads to lower inhibitory spiking activity, and reduces grid cells' ability to create stable representations of a novel environment. Furthermore, in animals with disrupted PNNs, exposure to a novel arena corrupted the spatiotemporal relationships within grid cell modules, and the stored representations of a familiar arena. Finally, we show that PNN removal in entorhinal cortex distorted spatial representations in downstream hippocampal neurons. Together this work suggests that PNNs provide a key stabilizing element for the grid cell network.
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Christensen, A. C., Lensjø, K. K., Lepperød, M. E., Dragly, S.-A., Sutterud, H., Blackstad, J. S., Fyhn, M., & Hafting, T. (2021). Perineuronal nets stabilize the grid cell network. Nature Communications, 12(1), 253. https://doi.org/10.1038/s41467-020-20241-w
Christensen, Ane Charlotte, et al. "Perineuronal nets stabilize the grid cell network." Nature Communications, vol. 12, no. 1, 2021, pp. 253, https://doi.org/10.1038/s41467-020-20241-w.
Christensen, Ane Charlotte, Kristian Kinden Lensjø, Mikkel Elle Lepperød, Svenn-Arne Dragly, Halvard Sutterud, Jan Sigurd Blackstad, Marianne Fyhn, and Torkel Hafting. "Perineuronal nets stabilize the grid cell network." Nature Communications 12, no. 1 (2021): 253. https://doi.org/10.1038/s41467-020-20241-w.
Christensen A. C., Lensjø K. K., Lepperød M. E. [и др.] Perineuronal nets stabilize the grid cell network // Nature Communications. — 2021. — Vol. 12, № 1. — P. 253. — URL: https://doi.org/10.1038/s41467-020-20241-w
@article{christensen2021perineuronal,
title = {{Perineuronal nets stabilize the grid cell network}},
author = {Ane Charlotte Christensen and Kristian Kinden Lensjø and Mikkel Elle Lepperød and Svenn-Arne Dragly and Halvard Sutterud and Jan Sigurd Blackstad and Marianne Fyhn and Torkel Hafting},
journal = {Nature Communications},
year = {2021},
volume = {12},
number = {1},
pages = {253},
doi = {10.1038/s41467-020-20241-w},
url = {https://doi.org/10.1038/s41467-020-20241-w}
}TY - JOUR AU - Christensen, Ane Charlotte AU - Lensjø, Kristian Kinden AU - Lepperød, Mikkel Elle AU - Dragly, Svenn-Arne AU - Sutterud, Halvard AU - Blackstad, Jan Sigurd AU - Fyhn, Marianne AU - Hafting, Torkel TI - Perineuronal nets stabilize the grid cell network JO - Nature Communications VL - 12 IS - 1 SP - 253 PY - 2021 DA - 2021/01/11 DO - 10.1038/s41467-020-20241-w UR - https://doi.org/10.1038/s41467-020-20241-w ER -
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